轻中度腕管综合征药物治疗长短期疗效  

Long-and short-term effects of drugs on treating mild-to-moderate carpal tunnel syndrome

作　　者：吴鹏[1] 杨剑云[1] 陈琳[1] 虞聪[1] 

机构地区：[1]复旦大学附属华山医院手外科,200040

出　　处：《国际骨科学杂志》2012年第4期270-271,277,共3页International Journal of Orthopaedics

摘　　要：目的探讨轻中度腕管综合征药物治疗的长短期疗效。方法门诊随访24例(35腕)口服四联药(弥可保、地巴唑、维生素B1、维生素B6)的轻中度腕管综合征病人。病人在入组时、治疗4个月、6个月后及停药1年后来我院门诊随访,向医生汇报其近期临床症状表现,自评其患手功能并填写Boston腕管问卷调查表(BCTQ)。病人在入组时及治疗6个月后,需接受患肢桡侧3指感觉神经传导速度(SNCV)检测。结果药物治疗后病人临床症状明显好转,短期(4个月、6个月)临床有效率可高达94.3%,长期(停药后1年)临床有效率可高达91.4%。BCTQ功能总评分及桡侧3指SNCV也较治疗前有明显恢复。结论弥可保联合地巴唑、维生素B1及维生素B6治疗轻中度腕管综合征有很好的长短期疗效。Objective To investigate the long- and short-term efficacy of drug combination therapy for mild-to-moderate carpal tunnel syndrome. Methods Twenty-four outpatients with mild to-moderate carpal tunnel syndrome （35 involved carpals ） treated with 4 drugs （methycohal, bandazol, vitB1 and vitB6） were followed up. The patients were asked to fill in the Boston carpal tunnel questionnaire （BCTQ） and their clinical symptoms were collected at each follow-up period （short-term at the 0 month, 4 months, 6 months after the start of treatment, and long term at 1 year after the end of treatment）. Sensory nerve conduction velocity （SNCV） of the involved radial three digital nerves was tested at the 0 month and 6 months after the start of treatment. Results The long- and short-term efficacy of drug treatment on mild-to-moderate carpal tunnel syndrome were 94. 3% and 91.4%, respectively. Obvious recovery of total BCTQ functional scores and SNCV were obtained after the drug treatment compared to the pre-treatment. Conclusion Both long- and short-term efficacy of drug combination therapy （methycohal, bandazol, vitB1 and vitB6） for mild-to-moderate carpal tunnel syndrome are good.

关 键 词：腕管综合征 保守治疗 弥可保 联合用药 

分 类 号：R688[医药卫生—骨科学]