慢性肾脏病钙、磷及甲状旁腺激素水平变化的对比分析  

Chronic kidney disease in calcium, phosphorus and parathyroid hormone level changes of comparative analysis

作　　者：岳华 刘红 徐世茹 侯佳 

机构地区：[1]维吾尔自治区人民医院肾脏病研究室,新疆830001

出　　处：《国际泌尿系统杂志》2012年第4期472-474,共3页International Journal of Urology and Nephrology

摘　　要：目的观察各期慢性肾脏病（CKD）患者的钙、磷及甲状旁腺激素（PTH）水平并分析其临床特征，为早期防治提供依据。方法选择2006年1月至2010年12月在新疆自治区人民医院肾病科住院的CKD患者294例，检测血清磷（P）、钙（Ca）、肌酐（Cr）、血清白蛋白（ALB）、CaP及血清甲状旁腺激素（PTH）的浓度。并进行回顾性分析。结果CKD1～2期患者血清钙、磷与对照组比较无显著性差异。CKD2期患者血清肌酐与对照组比较有显著性差异（P〈0．05）。CKD3～5期患者血清钙浓度低于对照组（P〈0．05），与CKD1～2期比较有差异，CKD5期患者血清钙浓度明显低于CKD3～4期有显著性差异。CKD3～5期患者血磷高于对照组及CKD1～2期，有显著性差异（P〈0．01），血磷增高明显与血钙和PrH有显著性差异（P〈0．05）。CKD2～5期患者血肌酐高于对照组及CKD1期患者有显著性差异（P〈0．01），与各组间比较亦无明显差异。结论对于CKD3期患者我们应该积极给予降低血磷的综合治疗，以防治继发性甲状旁腺功能亢进发生。Objectives Observe all issues of chronic kidney disease （CKD） patients of calcium, phosphorus and parathyroid hormone（PTH） level, analysis the clinical features, and providing the basis for the early prevention and control. Methods Choose in January 2006 to December 2010 in department of nephropathy of the People Hospital of Xinjiang Uyghur Autonomous Region with CKD of 294 cases in patients, The measurement of serum phosphorus （P）, calcium （Ca）, creatinine （Cr）, serum albumin （ALB）, CaP and serum parathyroid hormone （PTH） concentrations. And were retrospectively analyzed. Results By stages CKD1 - 2 patients＇serum calcium, phosphorus were compared with control group no significant differences. CKD2 in serum creatinine and control group patients with significant difference （ P 〈 0.05 ）. CKD3 -5 patients serum calcium concentration lower than those of the control group （P 〈0.05）have significant difference,And compared with CKD1 -2 there were More differences, CKD5 period patients serum calcium concentration significantly lower than CKD3 - 4 period. CKD3 - 5 patients serum phosphorus higher than those in the control group and CKD1 -2, have Signifieant difference（ P 〈 0.01 ）, obviously Increased serum phosphorus with the serum calcium and PTH have significant difference （ P 〈 0.05 ）. CKD2 - 5 patients serum creatinine higher than those in the control group and CKD1 period patients have significant difference（ P 〈 0.01 ）, And there were no significant differences between groups. Conclusions For CKD3 period of the patients we should actively take comprehensive treatment of reduce serum phosphorus, prevention and cure to secondary hyperparathyroidism happen.

关 键 词：肾疾病 慢性病 钙 磷 甲状旁腺激素类 

分 类 号：R692.5[医药卫生—泌尿科学]