间充质干细胞移植治疗小儿脑瘫疗效分析  

Effects of mesenchymal stem cell grafting on children with cerebral palsy

作　　者：杨静[1] 滑蓉蓉[1] 郑培[1] 刘岩松[1] 牛鑫鑫[1] 程洪斌[1] 王晓东[1] 

机构地区：[1]武警总医院干细胞移植科,北京100039

出　　处：《武警医学》2012年第7期586-589,592,共5页Medical Journal of the Chinese People's Armed Police Force

基　　金：国家教委留学回国人员科研启动基金资助(WZ2011001);广东省战略性新兴产业核心技术攻关项目资助(2011A081401003)

摘　　要：目的观察及对比分析自体骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)和脐血间充质干细胞(umbilical cord blood mesenchymal stem cells,UCBMSCs)移植治疗小儿脑瘫(cerebral palsy,CP)的临床疗效。方法 CP患儿60例,随机分入BMSCs移植组和UCBMSCs移植组,并接受术后6个月的随访,观察对比两组患儿术前与术后高级智能和肢体运动功能的变化。结果两组高级智能均有改善(包括:智力、语言、性情),高级智能功能改善率差异无统计学意义(7.5%vs 6.7%,P>0.05)。术后6个月运动功能两组较术前均有改善,BMSCs移植组在竖头(14.3%vs 2.7%)、身体居中性(7.7%vs 2.7%)、翻身(6.7%vs 0)、双上肢抓握等改善率均显著高于UCBMSCs移植组(P<0.01)。结论 UCBMSCs和BM-SCs移植对高级智能功能均有改善;而BMSCs移植对CP患者活动功能改善显著优于UCBMSCs移植。Objective To analyze and compare the clinical effects of bone marrow mesenchymal stem cells（BMSCs） grafting with that of umbilical cord blood mesenchymal stem cells（UCBMSCs） grafting in children with cerebral palsy.Methods Sixty hospitalized patients with cerebral palsy were enrolled from January 1,2008 to January 1,2009.They were randomly divided into two groups： UCBMSCs graft group（n=45） and BMSCs graft group（n=15）.In all patients recording of the mental and motor representation was performed before grafting,and followed-up in the end of 6 months after grafting.The content of comparison included high-level intelligence and motor function.SPSS16.0 was used for statistical analysis.Results Sixty patients were recruited in the study.Forty-five patients received UCBMSCs grafting,while fifteen patients received BMSCs grafting.The intelligence in the end of 6 months after grafting all have improved,including mentality,language,temperament in the two groups,but there was no significant difference（P〉0.05）.The motor function including raising head,body at neutral,turning over,grip with hands have improved significantly（P〈0.001） in the end of 6 months after grafting.Conclusion The improvement rates of intelligence,language and temperament in UCBMSCs grafting group are not significantly different from those in BMSCs grafting group.However,the improvement of gross motor function in BMSCs grafting group is significantly better than that in UCBMSCs grafting group.

关 键 词：骨髓间充质干细胞 脐血间充质干细胞 脑瘫 

分 类 号：R617[医药卫生—外科学]