产妇IgG抗体效价与新生儿溶血病相关性分析  

Relationship between IgG Antibody Titer and Hemolytic Disease of Newborn

作　　者：李锦荣[1] 何秋贤[1] 何日德[1] 

机构地区：[1]广东省佛山市顺德区第一人民医院检验科,广东佛山528300

出　　处：《黑龙江医学》2012年第7期488-489,492,共3页Heilongjiang Medical Journal

摘　　要：目的探讨产妇不同孕期IgG抗体效价与新生儿溶血病(HDN)的相关性。方法 318例夫妇ABO血型不合的O型孕妇,采用微柱凝胶技术测得抗A(B)效价、HDN血型血清学3项试验。结果 318例夫妇ABO血型不合中,O-A、O-B、O-AB组合,分别占49.7%(158/318)、42.7%(136/318)、7.5%(24/318)。孕妇血清IgG抗A(B)抗体效价≥128的病例占48.1%(153/318),不同血型组合间血清IgG抗A(B)抗体效价≥128的病例无显著性差异(P>0.05),均有发生新生儿HDN的可能。孕妇血清IgG抗A(B)抗体效价≥128的病例中新生儿HDN发生率为49.0%(75/153),新生儿HDN发生率随着孕妇血清IgG抗A(B)抗体效价水平的增加而升高。结论新生儿HDN发生率与IgG抗A(B)抗体效价成正比,定期检测血清IgG抗体效价水平,对防治新生儿HDN具有重要作用。Objective To explore the relationship between IgG antibody titer and hemolytic disease of newborn （HDN）. Methods 318 couples whose blood type were O with ABO - incompatible were studed. IgG antibody ti- ter was measured by means of microtubes gel test. Results The OA, OB, O - AB combination accounted for 49.7% （158/318） ,42.7% （136/318）, 7.5% （24/318）. The cases with serum IgG anti -A, （B） antibody ti- ter of〉~128 accounted for 48.1% （153/318）. Serum IgG anti - A, （B） antibody efficiency price 〉1128 among different blood type combinations had no significant difference （ P 〉 0. 05 ）, with the possibility of newborn HDN occurred. HDN rate in cases with serum levels of IgG anti -A（B） antibody titer ≥128 was 49.0% （75/153）, the incidence of HDN level increased with maternal serum levels of IgG anti - A （B） increasing. Conclusion The neonatal HDN incidence of IgG anti - A （B） is proportional to the antibody titer. Detecting serum IgG anti - antibody titer levels regularly has an important role in the prevention and treatment of neonatal HDN.

关 键 词：IGG抗体 新生儿溶血病 孕妇 

分 类 号：R446.62[医药卫生—诊断学]