Oscillatory and anti-oscillatory motifs in genetic regulatory networks  

作　　者：叶纬明 张朝阳 吕彬彬 狄增如 胡岗 

机构地区：[1]Department of Systems Science,School of Management and Center for Complexity Research,Beijing Normal University,Beijing 100875,China [2]Department of Physics,Beijing Normal University,Beijing 100875,China [3]General Research Institute for Nonferrous Metals,and Grirem Advanced Materials Co.Ltd.,Beijing 100088,China

出　　处：《Chinese Physics B》2012年第6期10-18,共9页中国物理B（英文版）

基　　金：Project supported by the National Natural Science Foundation of China (Grant No. 10975015);the National Basic Research Program of China (Grant No. 2007CB814800)

摘　　要：Recently, self-sustained oscillatory genetic regulatory networks （GRNs） have attracted significant attention in the biological field. Given a GRN, it is important to anticipate whether the network could generate oscillation with proper parameters, and what the key ingredients for the oscillation are. In this paper the ranges of some function-related parameters which are favorable to sustained oscillations are considered. In particular, some oscillatory motifs appearing with high-frequency in most of the oscillatory GRNs are observed. Moreover, there are some anti-oscillatory motifs which have a strong oscillation repressing effect. Some conclusions analyzing these motif effects and constructing oscillatory GRNs are provided.Recently, self-sustained oscillatory genetic regulatory networks （GRNs） have attracted significant attention in the biological field. Given a GRN, it is important to anticipate whether the network could generate oscillation with proper parameters, and what the key ingredients for the oscillation are. In this paper the ranges of some function-related parameters which are favorable to sustained oscillations are considered. In particular, some oscillatory motifs appearing with high-frequency in most of the oscillatory GRNs are observed. Moreover, there are some anti-oscillatory motifs which have a strong oscillation repressing effect. Some conclusions analyzing these motif effects and constructing oscillatory GRNs are provided.

关 键 词：genetic regulatory network  oscillatory motif anti-oscillatory motif feedback loop 

分 类 号：Q75[生物学—分子生物学]