2008～2010年浙江省25家医院药品TOP20合理性分析  

Rational Analysis of TOP 20 Drugs in 25 Hospitals of Zhejiang during 2008～2010

作　　者：冯胜民[1] 张幸国[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《药品评价》2012年第11期28-32,共5页Drug Evaluation

摘　　要：目的:探讨浙江某地区医院用药金额排名前20位的(TOP20)药品结构特点及用药合理性。方法:根据某地区16家三级医院和9家二级医院2008年～2010年的用药数据,采用金额分析法和循证分析法进行统计分析。结果:该地区25家医院TOP20购药金额三年呈逐年上升趋势;胸腺肽、人血白蛋白、质子泵抑制剂位居前三;抗感染药物的药品个数最多,以β-内酰胺类和氟喹诺酮类为主,不过排名次序有所下降,抗感染药物占前20位购药总额比例历年依次为32.92%、27.88%和33%;氯化钠的用量逐年增加;2009年辅助用药有8个;抗肿瘤药的排名逐年上升。结论:抗感染药的临床使用需要有所规范;静脉输液的给药途径过多;TOP20的药品结构不尽合理;非一线治疗药数量偏多,胸腺肽、神经节苷脂、奥拉西坦的使用与循证医学要求不尽相符,临床用药的思路有待探讨。Objective： To explore the constructional characteristics and rationality of the use of TOP 20 drugs in Zhejiang area. Methods~ The consumption data of drugs were analyzed by sum of money and evidence-based analysis according to the data of 16 tertiary hospitals and 9 secondary hospitals in the area during 2008-2010. Regults： The expenses for the purchase of TOP 20 drugs have been increasing from 2008 to 2010. TOP 3 were thymosin, albumin and proton pump inhibitors, respectively, in sum order. Antimicrobials have been ranking No 1 in quantity while the ranking declined, and β-1actams and fluoroquinolones have been accounted for the most, their purchase percent was 32.92%, 27.88% and 33% over the years. Consumption of sodium chloride rise year by year. The quantity of assistant drugs were 8. The rank of drugs for malignant tumors rise year by year. Conclusions： Clinical use of antimicrobials needs to be regulated. Administration ways of intravenous transfusion were too much. Constructional composition of TOP 20 was not so reasonable. The quantity of non-first-line treatment drugs was too much. Clinical applications of thymosin, gangliosides and oxiracetam were not so concordant with evidence-based medicine. The train of thought of clinical application of drugs needs to be further discussed.

关 键 词：金额分析 循证分析 合理用药 胸腺肽制剂 神经节苷脂 奥拉西坦 

分 类 号：R956[医药卫生—药学]