三维全深度复频域光学相干层析成像系统及其对人体皮肤的在体成像  

Three-Dimensional Full-Range Complex Fourier Domain Optical Coherence Tomography System for-Vivo-Imaging of Human Skin

作　　者：南楠[1,2] 步鹏[1] 郭昕[1,2] 王向朝[1,2] 

机构地区：[1]中国科学院上海光学精密机械研究所信息光学与光电技术实验室,上海201800 [2]中国科学院研究生院,北京100049

出　　处：《中国激光》2012年第7期120-125,共6页Chinese Journal of Lasers

基　　金：国家自然科学基金(60938003;60878092)资助课题

摘　　要：基于正弦相位调制建立了用于人体皮肤在体三维成像的全深度复频域光学相干层析(FDOCT)成像系统。通过在不同横向位置获取的干涉谱信号中引入正弦相位调制,利用傅里叶变换结合带通滤波的方法重建复干涉谱信号,使成像深度范围扩大为原来的两倍,且适合对活体组织进行在体成像。通过优化相位调制周期内的采样点数,提高了镜像抑制比。基于该系统在体获得了人体皮肤的三维全深度层析图,图中角质层、表皮层及真皮乳突层等皮肤层状结构清晰可见,镜像消除比约为36dB。A three-dimensional （3D） full-range complex Fourier domain optical coherence tomography （FDOCT） system based on sinusoidal phase-modulating method is developed for vivo imaging of human skin. A complex spectral interferogram is retrieved based on Fourier transform analysis and bandpass filter of phase-modulated interference spectra, which is recorded with sinusoidal phase modulation introduced during lateral beam scanning. With the system, the depth imaging range is doubled and the signal-to-noise ratio degrading with the lateral scanning is avoided. Also the system is suitable for vivo imaging. 3D vivo full-range OCT images of human skin is achieved with the proposed system. In the images, the stratum corneum, the epidermis and the upper dermis can be clearly identified. By optimizing the sampling number in one modulation period, the complex conjugate rejection ratio is improved, which is about 36 dB.

关 键 词：成像系统 医疗与生物成像 光学相干层析 正弦相位调制 

分 类 号：TN247[电子电信—物理电子学]