糖尿病肾病患者血清脂蛋白(a)和D-二聚体检测的临床研究  

The Clinical Study of Serum Lipoprotein(a) and D-dimer in Patients of Diabetic Nephropathy

作　　者：杜月菊[1] 邢志伟[1] 孙志平[1] 孙红梅[1] 刘相[1] 

机构地区：[1]河北省胸科医院,河北石家庄050041

出　　处：《中国药物经济学》2012年第2期79-80,共2页China Journal of Pharmaceutical Economics

摘　　要：目的分析糖尿病肾病患者血清脂蛋白、D-二聚体的水平变化及与糖尿病肾病的关系。方法根据尿白蛋白排泄率(Urinary Albumin Excretion rate,UAE)将134例2型糖尿病(Diabetes Mellitus,DM)患者分为单纯糖尿病组(Simple Diabetic Mellitus,SDM组)和糖尿病肾病组(DN组),200例健康体检者作为正常对照组分别测定各组血清Lp(a)、D-D的水平。结果 SDM组Lp(a)和D-D水平与健康对照组比较无统计学差异(P>0.05),但DN组Lp(a)和D-D水平显著高于健康对照组(P<0.01)。结论 DN患者血清Lp(a)和D-D水平明显升高,在DN的早期诊断和病情监测有一定意义。Objective To analyze the relationship between DN and the levels of serum Lp （a） and D-D in patients of DN. Methods According to UAE, 134 patients of type 2 DM were divided into SDM group and DN group and 200 healthy volunteers were divided into normal group control. To detect the levels of Lp （a） and D-D in each group. Results Comparing with healthy group control the levels of Lp （a） and D-D had no statistically difference in group SDM （P〉0.05）,but their levels in group DN significantly higher than healthy group control （P〈0.01）. Conclusion The levels of serum Lp （a） and D-D significantly increased in patients of group DN and there was a certain sense about earlv diac]nosis and disease monitorinq in DN.

关 键 词：糖尿病肾病 D-二聚体 脂蛋白(a) 血脂 血糖 

分 类 号：R654.2[医药卫生—外科学]