和厚朴酚对自发性高血压大鼠血清TNF-α作用研究  

The Effect on Serum TNF-αof Spontaneously Hypertensive Rats Treated by Honokiol

作　　者：张根水[1] 罗柳金[1] 侯宁[1] 张贵平[1] 

机构地区：[1]广州医学院药理学教研室,广东广州510182

出　　处：《现代中医药》2012年第4期79-80,共2页Modern Chinese Medicine

基　　金：广州医学院博士基金项目(2009-17)

摘　　要：目的观察和厚朴酚对自发性高血压大鼠血清TNF-α水平的影响。方法和厚朴酚低、高剂量组分别灌胃和厚朴酚200mg/(kg·d)、400mg/(kg·d);卡托普利组给予卡托普利30mg/(kg·d);对照组给予相同容积溶媒。给药7W后ELISA法测血清TNF-α水平。结果和厚朴酚低、高剂量两组大鼠血清TNF-α水平明显低于空白对照组(P<0.05),分别为(84.07±6.91)pg/mL、(81.69±7.15)pg/mL,与对照组(97.81±7.82)pg/mL比较差异具有显著性。结论和厚朴酚能明显降低自发性高血压大鼠血清TNF-α水平,抑制自发性高血压大鼠高系统炎症。Objective To observe the effect of honokiolon on serum TNF -α in spontaneous hypertensive rats. Methods The rats were divided into four groups. The low and high dose groups of honokiolon were intragastric filled by the dosage of 200 mg/（ kg · d） and 400 rag/（ kg · d） respectively. The blank control group was given orally the same volume of solvent and the control group by Captopril and dose was 30 mg/（ kg · d）. Seven weeks later, we measured the level of TNF - α in serum with ELISA. Results The serum levels of TNF - α in the low and high dose groups of honokiolon were significantly lower than that of blank control group（ P 〈0.05 ）. Conclusions Honokiol can significantly reduce the serum level of TNF - α of spontaneously hypertensive rats and restrain the systemic inflammation.

关 键 词：和厚朴酚 自发性高血压大鼠 高血压 炎症 肿瘤坏死因子 

分 类 号：R285.5[医药卫生—中药学]