咳嗽变异性哮喘患儿气道反应性特点  

Characteristics of the airway reactivity of children with cough variant asthma

作　　者：夏宇靖[1] 张琴[1] 袁艳[1] 万莉雅[1] 

机构地区：[1]天津市儿童医院,天津300074

出　　处：《临床儿科杂志》2012年第8期730-733,共4页Journal of Clinical Pediatrics

摘　　要：目的了解咳嗽变异性哮喘(CVA)患儿气道反应性特点。方法对38例CVA患儿、42例典型哮喘患儿和30例健康儿童进行肺功能和气道反应性测定。结果 CVA组和典型哮喘组患儿的气道反应性测定中的初始阻力值(Rrs cont)、基础呼吸传导率(Grs cont)与对照组比较差异无统计学意义;而最小诱发累积剂量(Dmin)、传导率下降斜率(SGr)和特异性气道传导下降第35百分位(PD35)均低于对照组,差异有统计学意义(P<0.05)。结论 CVA与典型哮喘患儿气道敏感性和气道反应性高于正常儿童,存在气道高反应。气道反应性测定可成为鉴别诊断慢性咳嗽的重要方法之一。Objective To investigate the characteristics of the airway reactivity of children with variant cough asthma （CVA）. Methods Lung function and airway reactivity of 38 cases of CVA, 42 cases of classic asthma （CA） and 30 healthy children were tested using an Astograph. Results Neither the CVA group nor the CA group had significant differences in respiratory resistance nor control value of the respiratory conductance compared with the control group. Other parameters reflecting the airway reactivity and sensitivity such as the minimum dose of methacholine, linear slope of the respiratory conductance decreased and the 35% drop in specific airways conductance in both of the CVA and the CA groups were significantly lower than those in the control group （P 〈 0.05）. Conclusions The CVA and CA children had higher airway reactivity and sensitivity than the control, and bronchial hyperresponsiveness existed in these conditions. So measurement of airway reactivity can be an important and useful method in the differential diagnosis of chronic cough.

关 键 词：咳嗽变异性哮喘 气道反应性 慢性咳嗽 儿童 

分 类 号：R725.6[医药卫生—儿科]