维生素D的免疫调节作用与儿童疾病  

Immunomodulating effect of vitamin D and children's diseases

作　　者：李海园[1] 刘志伟[1] 

机构地区：[1]上海交通大学附属国际和平妇幼保健院,上海200030

出　　处：《临床儿科杂志》2012年第8期792-794,共3页Journal of Clinical Pediatrics

基　　金：上海市自然科学基金资助项目(No.52010111)

摘　　要：维生素D不仅参与钙磷代谢,而且还是一类重要的免疫功能调节剂。维生素D主要通过调节各种免疫细胞的生长、分化和功能,影响细胞因子和抗微生物肽的分泌,在固有性免疫和适应性免疫中发挥重要作用。研究发现,维生素D缺乏与儿科急性下呼吸道感染、糖尿病和哮喘等疾病的发生发展相关。文章就维生素D的免疫调节作用及其与儿童疾病的相关性作一综述。Vitamin D, participating in calcium and phosphorus metabolism, is an important functional immune regulator. Vitamin D plays an important role in modulating both innate and adaptive immune responses, mainly through the modulation of growth, differentiation and function of a variety of immune cells, and the influence of secretion of cytokines and antimicrobial peptides. Studies show a close association between vitamin D deficiency and pediatric diseases such as acute lower respiratory infection, diabetes and asthma. The purpose of this paper is to review immunomod- ulating effect of vitamin D and the correlation between vitamin D and children＇ s diseases.

关 键 词：维生素D TOU样受体 巨噬细胞 树突状细胞 调节性T细胞 

分 类 号：R725.8[医药卫生—儿科]