转录后基因调控异常与老年性痴呆  

Impaired Post-transcriptional Regulation in Alzheimer′s Disease

作　　者：朱笠[1] 刘江红[1] 吴瑛[1,2] 

机构地区：[1]脑与认知科学国家重点实验室 中国科学院生物物理研究所,北京100101 [2]Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center,Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

出　　处：《生物化学与生物物理进展》2012年第8期703-708,共6页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展计划(973)(2009CB825400,2010CB529600);国家自然科学基金(91132710)资助项目~~

摘　　要：转录后基因调控异常与阿尔茨海默病(Alzheimer's disease,AD)发生发展的关系研究越来越受到重视.本文重点论述了tau基因(MAPT)发生可变剪接异常与AD发生的关系,以及参与转录后调控的RNA结合蛋白和非编码RNA在AD发生发展中的作用.Post-transcriptional regulation plays a central role in the development and maintenance of the nervous system. Defects in post-transcriptional regulation lead to neurodegenerative diseases. Mounting evidence suggests that the impaired post-transcriptional regulation of associated genes contribute to the neurodegenerative process, such as Alzheimer＇s disease （AD）. This review discusses the role of disruption of alternative splicing regulation of the human tau gene （MAPT） and alterations of microRNA expression in the pathogenesis of neurodegeneration including AD. A brief overview is provided for the role and the mechanism of post-transcriptional regulation in AD pathogenesis.

关 键 词：阿尔茨海默病 转录后调控 RNA剪接 RNA结合蛋白(RBPs) 非编码RNA(ncRNAs) 

分 类 号：Q52[生物学—生物化学] Q71