基于MRI的人脑海马结构的形态测量  

Measurement of hippocampal morphology in human brain by MRI

作　　者：刘智华[1] 钱学华[1] 周庭永[1] 吕发金[2] 郑登儒[1] 李林宏[1] 白桂芹[1] 张华[1] 

机构地区：[1]重庆医科大学:解剖学教研室法医学与生物医学信息研究室,400016 [2]重庆医科大学附属第一医院放射科,400016

出　　处：《第三军医大学学报》2012年第16期1636-1641,共6页Journal of Third Military Medical University

摘　　要：目的为与海马结构形态改变相关的疾病提供线性测量指标。方法选取重庆医科大学附属第一医院放射科51例经诊断无病变成人头部磁共振图片,观测海马体积、高度、宽度、长度等线性指标,数据经标准化处理后分析各线性指标与海马体积的相关性。结果数据经方差齐性检验后,运用单因素方差分析显示:标准化海马头体积、标准化海马体体积、标准化海马尾体积、标准化海马体积、标准化海马头长度、标准化海马体长度、标准化海马尾长度、标准化海马纵轴长度、标准化海马宽度、标准化颞角宽度性别间差异显著(女性>男性,P<0.05,P<0.01);钩回间距、颞角宽度性别差异显著(男性>女性,P<0.05,P<0.01);标准化海马头长度、标准化海马尾长度左右差异显著(右侧>左侧,P<0.05);标准化海马体长度、标准化海马纵轴长度左右差异显著(左侧>右侧,P<0.05)。利用Pearson相关分析显示:标准化后与海马体积相关程度最为密切的线性指标依次是海马宽度、海马纵轴长度、颞角宽度、海马尾体积。结论①海马结构形态存在性别及侧别上的差异;②海马宽度、纵轴长度等线性测量数据可以作为研究海马形态变化的初步筛选指标。Objective To provide linear measurement indices for hippocampal morphological change- related diseases. Methods The head magnetic resonance images of 51 healthy adults in the First Affiliated Hospital of Chongqing Medical University were analyzed. The volume, height, width and length of the hippocampus were measured, and the correlation of hippocampal volume with the height, width and length of the hippocampus were statistically analyzed after standardization. Results The standardized volume and length of hippocampal head, body and tail, standardized hippocampal volume, standardized length of hippocampal longi- tudinal axis, standardized hippocampal width and standardized temporal horn width were significantly greater in the females than in the males （P 〈0. 05 ,P 〈0. 01 ） , but the interuncal distance and the temporal horn width were significantly greater in the males than in the females （ P 〈 0.05, P 〈 0.01 ）. The standardized length of hippoeampus head and tail were greater at the right side than at the left side （P 〈 0. 05 ）, while the standardized length of hippoeampal body and hippocampal longitudinal axis were greater at the left side than at the right side （ P 〈 0. 05）. Pearson correlation analysis demonstrated that the liner indices which were the most closely correlated with hippocampal volume after standardization were the width of hippocampus, the length of hippocampal longitudinal axis, the width of temporal horn and the volume of hippocampal tail. Conclusion There are significant distinctions of hippocampal morphology in sex and side, which should be noted in clinical practice. The width of the hippocampus and the length of hippocampal longitudinal axis can be used as preliminary screening indices for morphological changes of hippoeampus.

关 键 词：海马结构 脑 MRI 

分 类 号：R322.811[医药卫生—人体解剖和组织胚胎学] R445.2[医药卫生—基础医学]