用于电穿孔效应实验的亚微秒脉冲电源  

The Sub-Microsecond Pulser Applied for Electroporation Effect

作　　者：谈亚芳[1] 杨宏春[1] 吴建星[1] 杨啸林[1] 张怡[2] 曾刚[1] 张晓宇[1] 

机构地区：[1]电子科技大学物理电子学院,成都610054 [2]四川大学华西妇女儿童医院,成都610041

出　　处：《生物医学工程学杂志》2012年第4期615-619,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(10804016)

摘　　要：针对肿瘤细胞电穿孔效应的实验需求,用幅值可调的高压直流电源为电容充电,具有一定时间延时的两路TTL信号分别控制串联的两个IGBT模块的通与断状态,以便从电容放电曲线中截取适当脉宽电脉冲的方法,研制了一台输出脉冲电压0.5～3.5kV连续可调,脉宽300～800ns准连续可调,重频1～400Hz连续可调的亚微秒脉冲电源。实验测试结果表明,这种脉冲电源性能稳定可靠,可用于恶性肿瘤电穿孔实验。A sub-microsecond pulse generation applied for electroporation effects of tumor cell is presented in this pa- per. The principle of the generator is that the expected pulse waveform is intercepted from the RC discharge curve by controlling the on-off states of two IGBT modules with a synchronous controller. Experimental tests indicate that the generator can produce adjustable pulse waveform parameters with 0.5-3.5kV amplitude, 300-800 ns pulse duration, 1-400Hz repetition frequency rate, and it is suitable for the study of the eleetroporation effect experiments.

关 键 词：脉冲电源 IGBT模块 电穿孔效应 

分 类 号：R318.0[医药卫生—生物医学工程]