特定行为下大鼠M1的LFPs研究  

Changes of Local Field Potentials in M1 Underlying the Specific Behavior in Rat

作　　者：赵以亮[1,2] 孙建涛[3] 宋永吉[3] 李芳[3] 艾洪滨[1] 王敏[1] 

机构地区：[1]山东师范大学生命科学学院,济南250014 [2]山东师范大学数学科学学院,济南250014 [3]山东科技大学信息与电气工程学院,青岛266510

出　　处：《生物医学工程学杂志》2012年第4期634-638,649,共6页Journal of Biomedical Engineering

基　　金：山东省自然科学基金资助项目(ZR2010CM055);山东省科技发展计划项目资助(2010GGX10133)

摘　　要：本文利用自制单通道微电极、多通道生理信号采集处理系统等,对大鼠抓食行为过程中初级运动皮层(M1)的局部场电位(LFPs)进行了记录,并根据所记录的LFPs的变化和与之同步的大鼠抓食行为变化,将大鼠抓食行为分为4个时期:抓食前期、计划期、抓食期和完成期,之后利用MATLAB软件通过时域分析、功率谱分布分析和时频分析的方法对不同时期的LFPs进行了研究。结果发现:大鼠在抓食行为过程中,M1前肢运动相关的神经元活动引发的LFPs变化对应于大鼠不同的行为状态,说明M1的LFPs起到了一定程度的"编码"作用,证明了用与前肢运动相关的M1的LFPs来识别前肢运动行为的可行性。The local field potentials （LFPs） underlying specific behavior were recorded and analyzed in this paper from primary motor cortex （M1） with several medium, such as the self-made single channel micro-electrodes, the system of multi-channels physiological signal acquisition and processing and so on. During the experiment, the spe- cific behavior was divided into four periods according to the changes of the recorded LFPs and the changes of the spe- cific behavior recorded simultaneously in rats. The four periods were named prophase of catching period, planning period, catching period and the completion period, respectively. Then several methods were used for the analysis of the LFPs by MATLAB, such as time domain analysis, power spectral distribution analysis and time-frequency analy- sis. The results suggested that the LFPs which were caused by different behavior from a large number of movement- related neurons of M1 during the specific behavior in the process of catching play an important part in the ＂code＂ guiding role in rats. The results demonstrat that the LFPs of M1 may provide a feasibility to discriminate the motor behavior of forelimb.

关 键 词：初级运动皮层 局部场电位 脑机接口 大鼠 MATLAB 

分 类 号：Q426[生物学—神经生物学] R318.04[生物学—生理学]