电阻抗谱评价模拟失重对大鼠血液电特性的影响  

Electrical Impedance Spectroscopy for Evaluation of the Influence of Simulated Weightlessness on the Electrical Properties of Rat Blood

作　　者：宫宇[1] 陈林[1] 沈斌[1] 马青[1] 

机构地区：[1]宁波大学医学院,宁波315211

出　　处：《生物医学工程学杂志》2012年第4期653-657,662,共6页Journal of Biomedical Engineering

基　　金：浙江省自然科学基金资助项目(Y207698);宁波市自然科学基金资助项目(2010A610074)

摘　　要：在频率为104～108 Hz范围,采用Agilent 4294A阻抗分析仪测量大鼠血液交流阻抗,通过电阻抗谱、Bode图、Nyquist图和Nichols图的数据分析,观察60d模拟失重(SWL)对大鼠血液电阻抗频谱特性的影响。结果表明:(1)大鼠血液电阻抗降低,主要表现在复阻抗实部(Z′0和Z′∞)、电阻抗幅模值(|Z*|0和|Z*|∞)、阻抗驰豫幅度(ΔZ′、Δ|Z*|)和低频阻抗幅模值对数(Log|Z*|0)较对照(CON)组均降低;(2)大鼠血液电阻抗谱的特征频率和相位角增加,主要表现在特征频率(fC1、fC2)和相位角[θP(degree)、θP(radian)]较CON组增加。提示模拟失重引起血液电阻率降低,导电性能增加。In the present study, the AC impedance of rat blood was measured with Agilent 4294A impedance analyzer in the frequency range of 10^4-10^8 H2, and the effect of simulated weightlessness （SWL）on electrical properties of rat blood was investigated by analyzing the data characteristics with the use of electrical impedance spectroscopy, the Bode diagram, the Nyquist diagram and the Nichols diagram. The results demonstrated 60 days SWL caused some changes： （1） the electrical impedance of rat blood were reduced, mainly in the real part of complex impedance （Z＇0 and Z∞）, the electrical impedance modulus amplitude （│Z＊│0and │Z＊│∞）, the impedance relaxation strength （△Z＇、△│Z＊│ ） and the logarithm of impedance modulus amplitude at low frequency（Log│Z＊│0 ） were lower than that in the control （CON） group; （2） the characteristic frequency of the electrical impedance spectrum of rat blood and the phase angle were increases, mainly in the characteristic frequency （fc1 , fc2） and the phase angle [θr（degree）、θr（radian）] increased compared with that in the CON group. These data indicate that SWL leads to reduced resistivity and enhanced conductivity of blood.

关 键 词：模拟失重 血液 电阻抗谱 BODE图 Nyquist图 Nichols图 

分 类 号：Q461[生物学—生理学] R318[医药卫生—生物医学工程]