骨缺损自修复过程中骨质体积变化规律分析  

Analysis on Changes of Sclerotin Volume During the Self-repairing Process of Bone Defect

作　　者：买买提江.马木提 买买提明.艾尼 尼加提.玉素甫 张瑞[2] 艾尔西丁.阿不来提 木合塔尔.玉素甫 艾克然木.马合木提 居来提.买提肉孜 买买提吐逊.吐尔地 

机构地区：[1]新疆大学机械工程学院,乌鲁木齐830047 [2]新疆医科大学第六附属医院影像中心CT室,乌鲁木齐830054 [3]新疆维吾尔自治区维吾尔医院骨科,乌鲁木齐830049 [4]新疆医科大学第一附属医院口腔颌面外科,乌鲁木齐830054

出　　处：《生物医学工程学杂志》2012年第4期682-686,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(50775193;50805125);青年教师科技培育基金资助项目(XJED2009S55);科技厅特培养项目资助(201123112)

摘　　要：骨骼自修复理论认为外荷载是骨骼重建的直接刺激源。本文介绍了骨缺损自修复过程的实验观测方法及相关观测结果。首先对兔子股骨开孔以破坏骨的连续性,建立骨缺损模型,然后利用CT扫描提取股骨数据,并用MIMICS软件来观测分析骨缺损后由生长因子引起的自修复过程,最后建立骨质体积变化关系,为仿生拓扑优化方法引入自修复机制提供科学依据。实验结果表明,在同样的条件下青年兔骨缺损部位各层骨质的修复比成年兔快得多,并且修复过程中软质骨与硬质骨体积变化之间存在着按一增一减的比例交叉变化的特性。Bone maintenance theory considers that the external load is the direct stimulating source of the bone remod- eling. In this article, the method of experimental observation of self-repairing process of the bone defect and related results are introduced. Firstly, a hole was drilled in the rabbit thighbone so that the continuity of the bone was changed. Then bone defect model was established, and the thighbone data were obtained by using CT scanning, and the self-repairing process of bone defects caused by growth factor were observed and analyzed by MIMICS software. Finally, the relationship between volume changes of sclerotin was established, and scientific bases were provided for introducing the bionic topology optimization method to the remodeling process. The experimental results showed that the self-repairing of the each layer sclerotin of the young rabbits was faster than that of the adult ones under the same condition. In addition, the volume always changes contrarily between the spongy bone and enamel bone during the self-repairing process of bone defect.

关 键 词：骨缺损 自修复 软质骨 硬质骨 

分 类 号：R681[医药卫生—骨科学]