体视学在放射影像学和细胞生物学方面的应用  

The Application of Stereology in Radiology Imaging and Cell Biology Fields

作　　者：胡纳[1] 汪曣[1] 冯远明[1] 林旺[1] 

机构地区：[1]天津大学精密仪器与光电子工程学院生物医学工程系,天津300072

出　　处：《生物医学工程学杂志》2012年第4期793-797,共5页Journal of Biomedical Engineering

摘　　要：体视学是由形态学与数学交叉形成的一门新兴学科,通过二维结构信息定量测量和分析三维形态结构特征。体视学的无偏、快速、精确、无损伤性和重复性高等特点,使得其被广泛地运用于组织学、病理学和医学影像学等生物医学领域的定量分析和统计中。体视学参数在不同病理情况中会表现出显著性差异,近年来很多学者利用体视学方法对其研究对象做定量分析,例如细胞癌变情况、肿瘤分级、病变的发展过程以及患者预后等。本综述主要介绍了体视学的概念和估算方法,举例体视学在CT图像、MRI图像以及细胞生物学方面的应用,体现了体视学运用的广泛性、优越性以及可靠性。Stereology is an interdisciplinary method for 3D morphological study developed from mathematics and mor- phology, It is widely used in medical image analysis and cell biology studies. Because of its unbiased, simple, fast, reliable and non-invasive characteristics, stereology has been widely used in biomedical areas for quantitative analysis and statistics, such as histology, pathology and medical imaging. Because the stereological parameters show distinct differences in different pathology, many scholars use stereological methods to do quantitative analysis in their studies in recent years, for example, in the areas of the condition of cancer cells, tumor grade, disease development and the patient＇s prognosis, etc. This paper describes the stereological concept and estimation methods, also illustrates the applications of stereology in the fields of CT images, MRI images and cell biology, and finally reflects the universali- ty, the superiority and reliability of stereology.

关 键 词：体视学 放射影像 定量分析 体视学参数 

分 类 号：R318.0[医药卫生—生物医学工程]