医用镁合金作为骨植入材料的研究进展  

Research Progress of Magnesium and Its Alloys as Orthopedic Implant Biomaterial

作　　者：王凤蛟[1] 庄金鹏[1] 周磊(综述)[1] 闫景龙(审校)[1] 

机构地区：[1]哈尔滨医科大学附属第一医院骨科,哈尔滨150001

出　　处：《生物医学工程学杂志》2012年第4期798-802,共5页Journal of Biomedical Engineering

摘　　要：镁合金具有生物可降解性、骨传导性、强度可调节性等特点,可避免二次手术带来的负担,但降解速度过快成为制约其生物医用的主要瓶颈。因此,镁合金的生物降解控制至关重要。本文对医用镁合金作为骨植入材料在体内、外的降解性,生物活性,生物相容性及耐腐蚀性能改进方面研究的主要进展做以下综述,分析可能的途径来改善其耐腐蚀性,实现生物降解的可控性。Magnesium based implants have the characteristics of bio-degradability, osteoconductive, and, regulatory strength. After the tissue has healed sufficiently, the burden of a second surgical procedure can be avoided. Howev- er, the degradation speed is so fast as to limit its clinical application. Hence, it is crucial for the biomedical magnesi- um alloys to be able to change their biodegradation behavior and speed. This paper reviews the degradability, biologi- cal activity and biocompatibility of magnesium and its alloys as orthopedic biomateriaI in vitro and vivo to explore the possible way to modify the characteristics of its degradability, for the purpose of controllable degradation speed.

关 键 词：镁合金 骨植入材料 生物降解 生物活性 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程] Q81[医药卫生—基础医学]