以纳米人工骨块充当间隔物在颈椎植骨后的融合  

Nano-hydroxyapatite artificial bone serves as a spacer for fusion with the cervical spine after bone grafting

作　　者：刘午阳[1] 莫建文[1] 高辉[1] 刘海丽[1] 王茂源[1] 何春耒[1] 唐文[1] 叶勇军[1] 

机构地区：[1]赣南医学院第一附属医院骨科,江西省赣州市341000

出　　处：《中国组织工程研究》2012年第29期5327-5330,共4页Chinese Journal of Tissue Engineering Research

摘　　要：背景:近年来椎板开门后多使用异体骨块和珊瑚人工骨等充当间隔物,结果易出现排异反应、不融合等情况。目的:验证纳米人工骨块在颈椎后路双开门椎管成形中的应用效果。方法:对46例行颈椎后路双开门椎管扩大成形的患者使用纳米人工骨块充当间隔物。随访3个月以上,比较纳米人工骨块置入前后日本骨科学会(JOA)评分,X射线和CT检测颈椎植骨融合状况。结果与结论:随访病例于末次随访时日本骨科学会(JOA)评分由置入前(7.9±1.9)分提高至(12.1±2.8),未见颈椎失稳和人工骨块松脱移位情况,纳米人工骨块和棘突融合良好。BACKGROUND： In recent years, allograft bone and coral bone have been commonly used as the spacers after double-door expansive laminoplasty, which can easily result in rejection and non-fusion. OBJECTIVE： To verify the effect of nano-hydroxyapatite artificial bone on posterior double-door expansive laminoplasty in the cervical spine. METHODS： Totally 46 patients undergoing posterior double-door expansive laminoplasty in the cervical spine received nano-hydroxyapatite artificial bone as the spacers. All patients were followed-up for over 3 months. Japanese Orthopaedic Association （JOA） scores before and after nano-hydroxyapatite artificial bone grafting were compared. The fusion of bone graft with the cervical spine was detected by X-ray and CT. RESULTS AND CONCLUSION： At final follow up, JOA scores were increased from preoperative （7.9±1.9） points to （12.1±2.8） points. No patients were found cervical spine instability as well as loosening and displacement of the bone graft postoperatively. The fusion between the nano-hydroxyapatite artificial bone and spinous process was good. These findings suggest that the nano-hydroxyapatite artificial bone is an ideal bone graft substitute material and applicable to double-door expansive laminoplasty.

关 键 词：纳米人工骨 双开门椎管扩大成形术 颈椎 日本骨科学会评分 棘突融合 

分 类 号：R318[医药卫生—生物医学工程]