聚氨基酸/羟基磷灰石椎间融合器植入山羊颈椎  

Intervertebral fusion cage made by poly-amino acid/hydroxyapatite composites in a goat cervical spine model

作　　者：彭磊[1] 权正学[1] 谭超[1] 欧云生[1] 唐可[1] 

机构地区：[1]重庆医科大学附属第一医院骨科,重庆市400016

出　　处：《中国组织工程研究》2012年第29期5345-5349,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家科技支撑计划项目(课题四2007BAE13B04)~~

摘　　要：背景：聚氨基酸/纳米羟基磷灰石复合材料已被研究证实具有良好的生物安全性.目的：观察聚氨基酸/羟基磷灰石椎间融合器对山羊颈椎的融合效果.方法：取成年雄性山羊,切除C3、4椎间盘,清除软骨终板,随机分成实验组与对照组,分别植入聚氨基酸/羟基磷灰石颈椎间融合器与自体髂骨.术后2,4,8,12 周行X射线检查;术后4,12 周行CT扫描和组织学检查.结果与结论：术后2 周,实验组平均椎间高度高于对照组（P 〈 0.05）,术后4～12 周,两组平均椎间高度差异无显著性意义.术后4 周,实验组融合度评分差于对照组（P 〈 0.05）,术后12 周两组融合度评分差异无显著性意义.术后4,12 周,两组均可观察到从成骨细胞集聚、胶原增生到新骨形成的过程.表明聚氨基酸/羟基磷灰石椎间融合器具有良好的初始稳定性和融合效果,是一种理想的椎间融合装置.BACKGROUD： Poly-amino acid/nano-hydroxyapatite composite material has been proved to have a good bio-security OBJECTIVE： To evaluate the fusion effect of poly-amino acid/nano-hyd roxyapatite interbody cage in a goat cervical spine model. METHODS ： Sixteen adult male goats underwent C3-4 discectomy and intervertebral fusion with poly-amino acid/nano-hydroxyapatite interbody cage （experimental group, n=8） or autogenous iliac （control group, n=8）. X-ray was taken at 2, 4, 8 and 12 weeks after surgery to measure the intervertebral height. CT scanning and histology examination were performed at 4 and 12 weeks after surgery. RESULTS AND CONCLUSION： Referring to radiography and histomorphology findings, the goats with poly-amino acid/nano-hydroxyapatite cage or autograft all showed fine fusion at 12 weeks, without significant difference. The intervertebral fusion cage of poly-amino acid/nano-hydroxyapatite has good initial stability and fusion which may be an ideal interbody fusion appliance.

关 键 词：聚氨基酸/羟基磷灰石 山羊颈椎 椎间融合器 融合 生物材料 

分 类 号：R318[医药卫生—生物医学工程]