新型带电荷硫酸钙/β-磷酸三钙复合骨水泥经单、双侧椎弓根注入椎体成形:渗漏及填充椎体的力学特征  

New charged calcium sulfate/beta-tricalcium phosphate compound bone cement for unilateral and bilateral transpedicular vertebroplasty:Bone cement leakage and biomechanics changes

作　　者：秦毅[1,2] 江建明[1] 朱青安[1] 瞿东滨[1] 杨勇[1] 刘鹏[1] 

机构地区：[1]南方医科大学南方医院脊柱外科,广东省广州市501515 [2]广东省中医院珠海医院骨伤二科,广东省珠海市519020

出　　处：《中国组织工程研究》2012年第29期5489-5492,共4页Chinese Journal of Tissue Engineering Research

摘　　要：背景:新型带电荷硫酸钙/β-磷酸三钙复合骨水泥在恢复椎体力学性能的同时,可进一步降低传统椎体成形骨水泥渗漏的风险,提高手术安全性。目的:观察新型带电荷硫酸钙/β-磷酸三钙复合骨水泥经单、双侧椎弓根椎体成形的渗漏和椎体生物力学变化。方法:选取8具老年男性尸体骨质疏松胸腰椎标本,建立椎体压缩性椎体骨折模型,将连续的2个椎体标本配成对子交叉分配到单、双侧组。单侧组行4mL新型带电荷硫酸钙/β-磷酸三钙复合骨水泥经单侧椎弓根椎体成形;双侧组行4mL新型带电荷硫酸钙/β-磷酸三钙复合骨水泥经双侧椎弓根椎体成形,每侧2mL。结果与结论:单侧组骨水泥混合渗漏高于双侧组(P<0.05)。两组椎体成形治疗后最大载荷与刚度差异无显著性意义(P>0.05)。表明行新型带电荷硫酸钙/β-磷酸三钙复合骨水泥椎体成形最好择双侧穿刺,减少每侧注入骨水泥移植材料的剂量有利于降低渗漏风险;经单、双侧注入填充椎体的生物力学无明显差异。BACKGROUND： A new type of charged calcium sulfate/beta-tricalcium phosphate compound bone cement can restore vertebral mechanical properties, and meanwhile reduce the risk for bone cement leakage in traditional vertebroplasty and improve operation safety. OBJECTIVE： To study bone cement leakage and vertebral biomechanical changes by observation of the new charged calcium sulfate/beta-tricalcium phosphate compound bone cement in unilateral and bilateral transpedicular vertebroplasty. METHODS： Osteoporotic thoracolumbar specimens selected from eight old male corpses were used to prepare a vertebral compression fracture model. Two successive vertebral specimens were paired to be cross-assigned into unilateral and bilateral groups. In the unilateral group, 4 mL of new charged calcium sulfate/beta-tricalcium phosphate compound bone cement was applied in unilateral transpedicular vertebroplasty; 4 mL of new charged calcium sulfate/beta-tricalcium phosphate compound bone cement was used for bilateral transpedicular vertebroplasty in the bilateral group, 2 mL at each side. RESULTS AND CONCLUSION： The leakage volume of bone cement in the unilateral group was significantly higher than that in the bilateral group （P 〈 0.05）. There was no significant difference in the maximum load and stiffness between the two groups （P 〉 0.05）. Bilateral transpedicular vertebroplasty with new charged calcium sulfate/beta-tricalcium phosphate compound bone cement is better, and the decreased volume of injected bone cement helps to reduce the leakage risk of bone cement. However, there is no difference between the vertebral biomechanical changed of the two groups.

关 键 词：硫酸钙/β-磷酸三钙 椎体成形 骨水泥 渗漏 刚度 生物材料 

分 类 号：R318[医药卫生—生物医学工程]