骨形态发生蛋白2纳米人工骨在成人特发性脊柱畸形矫正融合中的应用  

Application of bone morphogenetic protein 2 loaded nano-hydroxyapatite artificial bone in the correction and fusion of adult idiopathic scoliosis

作　　者：胡文[1] 黄旗凯[1] 苏佳灿[1] 李明[1] 

机构地区：[1]解放军第二军医大学附属长海医院骨科,上海市200433

出　　处：《中国组织工程研究》2012年第29期5497-5500,共4页Chinese Journal of Tissue Engineering Research

摘　　要：背景:复合骨形态发生蛋白2纳米人工骨具有独特的生物特性,模仿天然骨的成分及结构特征,可为细胞提供与天然骨相类似的微环境。目的:观察复合骨形态发生蛋白2纳米人工骨与同种异体骨植骨在成人特发性脊柱畸形矫正融合的临床效果。方法:回顾分析69例成人特发性脊柱侧弯患者资料,分别采用复合骨形态发生蛋白2纳米人工骨移植36例,同种异体骨移植33例,植骨后第3,6个月拍摄脊柱全长正侧位片,观察植骨融合情况。结果与结论:69例患者畸形明显矫正,3,6个月的影像学观测两组均可见骨小梁生长。植骨后6个月,复合骨形态发生蛋白2纳米人工骨组明显融合33例,同种异体骨组26例。复合骨形态发生蛋白2纳米人工骨组早期融合率高于同种异体骨组(P<0.05)。提示成人特发性脊柱侧凸后路矫形手术中,复合骨形态发生蛋白2纳米人工骨是比较理想的骨移植材料,在融合效果方面优于同种异体骨。BACKGROUND： Bone morphogenetic protein 2 （BMP-2） loaded nano-hydroxyapatite artificial bone has unique biological properties that can imitate the component and structure of natural bone. It can provide cells a microenvironment which is similar to that of natural bone. OBJECTIVE： To investigate the clinical effects of BMP-2 loaded nano-hydroxyapatite artificial bone and allogeneic bone grafting on the correction and fusion of adult idiopathic scoliosis. METHODS： A retrospective review of 69 patients with adult idiopathic scoliosis was performed. These patients were randomly divided into two groups： group A and group B. In group A, 36 patients were received BMP-2 loaded nano-hydroxyapatite artificial bone; in group B, 33 patients were received allogeneic bone grafting. The anterioposterior and lateral full spinal films were taken at 3 and 6 months after operation, and the spinal fusion status in the two groups were observed and compared. RESULTS AND CONCLUSION： All patients with adult idiopathic scoliosis have corrected obviously. The two groups were all found bone trabecula growth in the radiographs at 3 and 6 months. At 6 months after operation, 33 patients in group A and 26 patients in group B had fused significantly, and early fusion rate of group A was higher than that of group B （P 〈 0.05）. These findings suggest that BMP-2 loaded nano-hydroxyapatite artificial bone is an ideal artificial material for bone transplantation in the correction and fusion of adult idiopathic scoliosis, which is superior to allogeneic bone in spine fusion.

关 键 词：成人特发性脊柱侧弯 纳米人工骨 植骨 骨形态发生蛋白2 矫形 

分 类 号：R318[医药卫生—生物医学工程]