低频脉冲电磁场干预绝经后骨质疏松患者血清护骨素及核因子κB受体活化子配体的变化  

Effects of low frequency pulsed electromagnetic fields on the serum osteoprotegerin and nuclear factor-kappa beta ligand receptor activator in postmenopausal osteoporosis patients

作　　者：陈健[1] 黄慧[1] 何剑全[1] 黄礼群[2] 李武量[1] 

机构地区：[1]厦门大学附属中山医院康复科,福建省厦门市361004 [2]解放军广州军区武汉总医院康复科,湖北省武汉市430070

出　　处：《中国组织工程研究》2012年第30期5577-5580,共4页Chinese Journal of Tissue Engineering Research

基　　金：厦门市科技局资助项目(3502z20104031);厦门市卫生局资助项目(3502z20089036)~~

摘　　要：背景:脉冲电磁场能克服传统治疗方法的缺陷,对骨质疏松引起的疼痛、骨量减少、骨密度降低具有肯定的治疗作用。目的:探讨低频脉冲电磁场治疗绝经后骨质疏松的作用机制。方法:应用双能X射线骨密度仪测量150例绝经后妇女腰椎骨密度,按WHO标准诊断,无骨质疏松患者50例、骨质疏松患者100例。将骨质疏松患者随机分为骨质疏松组和低频脉冲电磁场治疗组,分别给予钙剂口服或钙剂口服+连续14d的低频脉冲电磁场治疗。结果与结论:各组患者基线资料具有可比性。与无骨质疏松患者比较,骨质疏松患者腰椎骨密度明显降低(P<0.01),经低频脉冲电磁场治疗后无明显改变(P>0.05),但患者血清β-1型胶原C-末端肽明显降低(P<0.05)、骨钙素明显升高(P<0.01)。与骨质疏松组比较,其他两组患者血清护骨素明显升高(P<0.05);低频脉冲电磁场治疗组患者血清核因子κB受体活化子配体明显降低(P<0.05)。说明低频脉冲电磁场干预14d对骨质疏松有良好的防治作用。BACKGROUND： Pulse electromagnetic fields （PEMFs） can overcome the defects of the traditional treatment and have the treatment function to osteoporosis causing pain, bone mass and bone mineral density reducing. OBJECTIVE： To investigate the mechanism of low frequency PEMFs on the treatment of postmenopausal osteoporosis. METHODS： 150 postmenopausal women were selected to measure the lumbar bone mineral density by dual-energy X-ray absorptiometry based on the WHO standard. The results showed there were 50 cases of no osteoporosis and 100 cases of osteoporosis. The patients with osteoporosis were randomly divided into osteoporosis group and low frequency PEMFs group; the patients in these two groups were treated with oral calcium or oral calcium＋14 days consecutive low frequency PEMFs. RESULTS AND CONCLUSION： Baseline materials in three groups were comparative. Women without osteoporosis showed higher levels of bone mineral density than women with osteoporosis （P 〈 0.01 ）, and were not changed after treated with low frequency PEMFs （P 〉 0.05）, but, the level of serum 13-CrossLaps was significantly decreased （P 〈 0.05）, the level of bone gamma-carboxyglutamic-acid-containing proteins was significantly increased （P 〈 0.01）. Compared with osteoporosis group, the level of serum osteoprotegerin was significantly increased in no osteoporosis group and low frequency PEMFs group （P 〈 0.05） and the level of serum osteoprotegerin, nuclear factor-kappa beta was significantly decreased （P 〈 0.05）. Low frequency PEMFs intervention for 14 days has a good preventive effect on osteoporosis.

关 键 词：低频脉冲电磁场 骨质疏松 护骨素 核因子κB受体活化子配体 绝经后 

分 类 号：R318[医药卫生—生物医学工程]