利多卡因和氟比洛芬酯联用治疗异丙酚注射痛的疗效观察  

Observation on Effect of Lidocaine Combined with Flurbiprofen Axetil on Reducing Pain during Injection of Propofol

作　　者：张彦东[1] 乔瑞东 芮海涛[1] 

机构地区：[1]珠海市人民医院,广东珠海519000

出　　处：《今日药学》2012年第6期369-371,共3页Pharmacy Today

摘　　要：目的评估利多卡因和氟比洛芬酯联用治疗异丙酚注射痛的疗效观察。方法将100例年龄22～69 a的患者(男55例,女45例)随机分成4组:安慰剂组(生理盐水);利多卡因40 mg组;氟比洛芬酯50 mg组;利多卡因-氟比洛芬酯联用组(n=25),静脉阻塞2min,然后手背静脉注射0.5 mg/kg的异丙酚。结果异丙酚注射痛在安慰剂组、利多卡因组、氟比洛芬酯组、联用组分别为88%、32%、40%和8%。结论利多卡因40 mg和氟比洛芬酯注射液50 mg联合治疗有效地降低了异丙酚注射痛。Objective To evaluate the efficiency of the combined therapy of lidocaine and flurbiprofen axetil for reducing pain during the injection of propofol. Methods One hundred patients aged 22-69 years old （55 men and 45 women） were divided into 4 groups： placebo （saline） ;lidocaine 40 mg; flurbiprofen axetil 50 mg, or both, with venous occlusion for 2 min, followed by administration of propofol 0.5 mg/kg into a dorsal hand vein. Results The rate of propofol-induced pain in patients of placebo group, lidocaine group, flurbiprofen axetil group, and combined group were 88%, 32%, 40% and 8%, respectively. Conclusion lidocaine/flurbiprofen axetil combination can effectively reduces pain during the injection of propofol.

关 键 词：异丙酚 疼痛 利多卡因 氟比洛芬酯注射液 

分 类 号：R969[医药卫生—药理学]