急性病毒性肝炎患者外周血T细胞亚群的检测和分析  

Detection of Peripheral Blood T Lymphocyte Subtypes in Acute Viral Hepatitis

作　　者：黄承乐[1] 黄红华[1] 丁凯宏[1] 班副植[1] 黎荣能[1] 

机构地区：[1]广西百色市人民医院检验科,广西百色533000

出　　处：《现代生物医学进展》2012年第18期3535-3537,共3页Progress in Modern Biomedicine

摘　　要：目的:检测急性甲、乙型病毒性肝炎患者外周血T淋巴细胞亚群变化,探讨其对疗效和预后意义。方法:采用APAAP桥联酶标法检测115例急性甲、乙型病毒型肝炎患者外周血CD3+、CD4+、CD8+T细胞亚群比例,计算CD4+/CD8+值。并检测了34例患者治疗前后T淋巴细胞亚群变化。结果:115例急性甲、乙型病毒性肝炎患者外周血CD3+、CD4+T细胞比例及CD4+/CD8+值均低于正常对照组(P<0.05),而CD8+T细胞比例均高于正常对照组(P<0.01)。6例无明显疗效者,各亚群比例在治疗前后无显著差异(P>0.05)。28例有明显疗效者,治疗后各亚群比例恢复正常水平,与治疗前相比差别具有统计学意义(P<0.05)。结论:急性甲、乙型病毒性肝炎患者外周血CD4+/CD8+T细胞比值可在一定程度上反映疗效及预后。Objective： To detect the ratio changes of peripheral blood T lymphocyte subtypes during acute viral hepatitis caused by HAV or HBV, explore the relationship between curative effect and these changes. Methods： 115 acute viral hepatitis patients were involved in this study. The values of T lymphocyte subtypes including CD3＋ CD4＋, CD8＋ and CD4＋/CD8＋ were measured by APAAP method. 34 patients were selected to observe T lymphocyte subtypes changes before and after therapy. Results： The values of CD3＋, CD4＋, CD4＋/CDs＋ in acute viral hepatitis patients were lower than in normal control group （P〈 0.05） while the CDs＋ were significantly higher （P〈0.01）. The values ofT lymphocyte subtypes had no significantly changes during therapy in 6 patients without curative effect （P〉0.05）. In contrast the values ofT lymphocyte subtypes came back to normal level in 28 recovered patients （P〈0.05）. Conclusion： The value of CD4＋/CD8＋ could be used to evaluate curative effect in acute viral hepatitis caused by HAV or HBV.

关 键 词：T细胞亚群 急性病毒性肝炎 

分 类 号：R512.6[医药卫生—内科学]