前体蛋白转化酶家族的重要成员之一:弗林蛋白酶  

An Important Member of the Family of Proprotein Convertases: Furin

作　　者：韩明[1] 杨允[1] 林宏宇[1] 黄艺娜[1] 

机构地区：[1]福建师范大学生命科学学院发育与神经生物学福建省高校重点实验室,福建福州350108

出　　处：《现代生物医学进展》2012年第18期3586-3588,共3页Progress in Modern Biomedicine

基　　金：福建省自然科学基金资助项目(2009J01127)

摘　　要：弗林蛋白酶(Furin)是前体蛋白转化酶家族的重要成员之一,广泛存在于各种组织和细胞系中。Furin经过两次自剪切去掉前肽后具有生理活性,能够识别特定的氨基酸序列并在TGN中对多种前体蛋白进行加工。Furin的作用底物不仅包括神经肽和肽类激素,还包括许多生长因子、受体、血浆蛋白酶、基质金属蛋白酶及细菌外毒素等,具有重要的生物学功能。Furin is a key member of the family of proprotein convertases, which is expressed in all tissues and cell lines. It will gain its bioactivity after two self-cleavages and activate many of her proproteins into their biologically active forms in the trans-Golgi net- work, because it can identify the specific amino acid sequence. Furin possesses important biological functions as it is capable of cleaving precursors of a wide variety of proteins, not only neuropeptides and peptide hormones, but also many growth factors,receptors, plasma proteases, matrix metalloproteinases and bacterial exotoxins.

关 键 词：弗林蛋白酶 内切蛋白酶 前体蛋白 

分 类 号：Q78[生物学—分子生物学]