京尼平苷的抗血栓基础研究(英文)  

Basic Research about Antithrombotic Effect of Geniposide

作　　者：刘昊[1] 张海燕[1,2] 宋伟[1] 芦乾[1] 李芳[1] 杨明[1,3] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004 [2]西南交通大学材料先进技术教育部重点实验室,四川成都610003 [3]成都中医药大学,四川成都611137

出　　处：《现代生物医学进展》2012年第19期3601-3604,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(2009ZX09103-393)~~

摘　　要：目的:明确京尼平苷和京尼平的抗血栓和纤溶的作用效果。方法:用旁路循环血栓形成模型和颈总动脉血栓模型,测定CT、BT、PRT、PT,全血溶栓,计算血栓形成抑制率。结果:试验表明,京尼平苷及其苷元能显著延长凝血、出血时间,减少两个血栓模型的血栓重量,京尼平苷高剂量组与阳性药组相比,溶栓作用具有显著性差异(P<0.05),优于阳性药;京尼平、京尼平苷抗凝血及抗血栓作用与阿司匹林组相比无显著差异(P>0.05)。结论:实验表明中药栀子能延长凝血和出血时间,可能有一定的抗血栓和溶栓作用。Objective： To make sure the antithrombotic and fibrinolytic effect of geniposide and genipin. Methods： The model of bypass loop thrombosis and carotid artery thrombosis were used to determine CT, BT, PRT, PT and weight of thrombus, then calculated the rate of thrombosis inhibition. Results： Tests showed that geniposide and genipin could remarkably extend time of blood coagulation and hemorrhage and reduce weight of thrombus. Compared with positive drug group（aspirin） genipin and geniposide high dose group had significant difference （P〈0.05） on anticoagulation and antithrombotic function. Geniposide low dose group had no significant difference on thromblytic activity and antiplatelet aggregation compared with aspirin group （P〉0.05）. Conclusion： Geniposide and its aglycon might have antithrombotic and fibrinolytic function.

关 键 词：京尼平苷 抗血栓 纤溶 凝血时间 出血时间 

分 类 号：R332[医药卫生—人体生理学] R322.61[医药卫生—基础医学]