缝隙连接蛋白43研究进展  

Progress on Connexin43

作　　者：李艳燕[1] 张博[1] 韩峰[1] 刘中洋[1] 金发光[1] 

机构地区：[1]第四军医大学唐都医院呼吸内科,陕西西安710038

出　　处：《现代生物医学进展》2012年第19期3731-3733,共3页Progress in Modern Biomedicine

基　　金：陕西省公关项目(2008K14-08);军队十一五公关项目(08-G102)

摘　　要：缝隙连接蛋白(Connexin,Cx)组成缝隙连接通道发挥其通讯功能,其本身也对细胞的生长、分化、凋亡、肿瘤具有调节作用。缝隙连接蛋白43(Cx43)在肺泡上皮和肺血管内皮高表达,在多种肺损伤的病理过程中起重要作用,因此成为研究热点。Cx43的表达和功能受多种因素的调节,丝裂原激活的蛋白激酶(MAPKs)是主要的调节途径。本文就Cx43在肺的病理生理过程中的作用及MAPK对其调节作用进行综述。Connexin43 （Cx43） is the main component of gap junctions in alveolar epithelium and ,zapillary endothelium, which is essential for intercellular information communication function. Cx43 is closely related to cell development, apoptosis. Cx43 is ubiquitous in both alveolar epithelial and endothelial cells, which is known as gap junction un-communication function. The expression of Cx43 in the lung can be altered in lung injuries such as radiation-induced pulmonary fibrosis, lipopolysaccharide or bleomycin-induced lung injury, and even in lung canner. Cx43 was regulated by Mitogen-activated protein kinase （MAPK） in pathological lungs. Therefore, Cx43 is thought to be a new therapeutic target to pulmonary disease.

关 键 词：缝隙连接蛋白43 肺损伤 

分 类 号：Q591.9[生物学—生物化学] Q51