糖尿病肾病致足细胞损伤特点的研究  

The Research on Characters of Podocytes Injury caused by Diabetic Nephropathy

作　　者：王万兴[1] 王丽晔[2] 郭思媛[2] 李峰[2] 

机构地区：[1]天津市武清区中医院,天津301700 [2]北京中医药大学,北京100029

出　　处：《现代生物医学进展》2012年第19期3774-3777,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金面上项目(30873217);国家自然科学青年基金项目(81001501);国家质量工程中医特色建设项目(TS2067)

摘　　要：足细胞是附着在肾小球基底膜外的高度分化的上皮细胞,在维持肾小球滤过屏障完整性及限制血浆蛋白的滤出方面均发挥重要作用。近年来,在糖尿病肾病的研究中发现,足细胞损伤对蛋白尿及肾小球硬化等病理变化均明显相关。本文就糖尿病肾病时足细胞损伤的特点作一简要概述,为以后的相关研究奠定基础。Podocyte is a kind of highly differentiated epithelial cells which attached to glomeroular basement meinbrance. Podocytes play a crucial role in preserving integrity of glomerular filtration barrier and maintaining specific restriction on filtration of plasma protein. In recent years, it was showed that the damage of podoeyte is related to proteinuria and glomerulosclerosis in the researching of diabetic nephropathy. This article reviews some papers in order to summarize the characters ofpodocytes injury caused by diabetic nephropathy and lay the foundation of correlational investigation.

关 键 词：足细胞损伤 糖尿病肾病 特点 

分 类 号：R587.2[医药卫生—内分泌]