雄激素受体基因(CAG)n多态性与男性2型糖尿病血管并发症相关性  

Correlation between androgen receptor gene(CAG)n polymorphism and male type 2 diabetic vascular complications

作　　者：毛达勇[1] 赵娟[1] 张吉才[1] 

机构地区：[1]湖北医药学院附属太和医院检验科,湖北十堰442000

出　　处：《分子诊断与治疗杂志》2012年第4期245-248,共4页Journal of Molecular Diagnostics and Therapy

摘　　要：目的研究雄激素受体(AR)基因(CAG)n多态性分布频率及其与2型糖尿病血管病变的关系。方法 DNA测序技术检测48例男性2型糖尿病血管并发症患者雄激素受体基因CAG串联重复序列(CAG-STR)长度,并分别与60例无血管并发症2型糖尿病患者和46例正常对照组比较。结果 CAG重复次数介于13～36,平均22.2,2型糖尿病伴血管性病变组CAG重复次数23.4±3.85,无血管并发症组22.3±3.57,正常对照组21.9±3.45,糖尿病血管病变组CAG-STR长度明显高于正常对照组和无血管病变组(P<0.05),CAG重复次数与HDL-C水平呈正相关。结论男性2型糖尿病血管并发症与雄激素受体基因(CAG)n多态性有关,雄激素受体CAG重复序列的长度可能是糖尿病血管病变的危险因素,越长CAG重复序列并发血管病变的可能性越大。Objective To study the relationship of androgen receptor（AR） gene（CAG） n polymorphism distribution frequency and type 2 diabetes angiopathy. Methods The length of androgen receptor gene CAG short tandem repeat（CAG-STR） sequences were detected by DNA sequencing in 48 cases of male type 2 diabetic patients with vascular complications, and compared with 60 without vascular complications and 46 normal controls respectively. Results The number of CAG repeats ranged from 13-36, with mean value 22.2. It was 23.4 ±3.85 in DM with vascular disease group, 22.3 ± 3.57 in DM without vascular disease group and 21.9 ± 3.45 in normal controls. Statistical analysis revealed that diabetic vascular lesion group CAG-STR length was significantly higher than that in no vascular lesion group and control group（P〈0.05）. The CAG number of repetitions were positively correlated with HDL-C levels. Conclusion male type 2 diabetic vascular complications associated with androgen receptor gene（CAG） polymorphism. The length of androgen receptor gene CAG repeat sequences is likely one of the risk factors of diabetic vascular disease, the longer CAG repeat sequences, the more likely vascular lesions occur.

关 键 词：2型糖尿病 血管并发症 雄激素受体 基因多态性 

分 类 号：R587.1[医药卫生—内分泌]