清热活血方治疗急性冠脉综合征临床观察  

Clinical Observation of Heat-clearing and Blood-activating Recipe for Acute Coronary Syndrome

作　　者：吴伟[1] 罗川晋[1] 李荣[1] 吴辉[1] 陈宇鹏[1] 黄衍寿[1] 

机构地区：[1]广州中医药大学第一附属医院心内科,广东广州510405

出　　处：《新中医》2012年第8期9-12,共4页New Chinese Medicine

摘　　要：目的:观察清热活血方治疗急性冠脉综合征(ACS)患者的临床疗效及安全性。方法:100例ACS患者随机分为2组各50例。治疗组予西医基础治疗加清热活血方,对照组予西医基础治疗加冠心2号方。2组均观察4周。观察2组患者治疗前后中医证候、血清超敏C反应蛋白(hs-CRP)、血小板聚集率等指标变化,及治疗后比较2组西雅图心绞痛量表评定积分。结果:总有效率治疗组76%,对照组46%,2组比较,差异有显著性意义(P<0.05)。治疗组治疗后胸闷、心悸、气短的症状积分、hs-CRP、血小板聚集率较治疗前降低(P<0.01),部分西雅图心绞痛量表评定积分明显优于对照组(P<0.01,P<0.05)。结论:清热活血方具有改善热毒血瘀证ACS患者临床症状、降低hs-CRP水平、发挥抗炎的作用。Objective： To observe the clinical effects and safety of Heat-clearing and Blood-activating Recipe （HBR） for acute coronary syndrome（ACS）. Methods： One hundred ACS patients were randomized into treatment group and control group, 50 cases in each group. The two groups were given routine western medicine, and the control group was treated with No. 2 Coronary Recipe and the treatment group with HBR. After treatment for 4 weeks, the changes of traditional Chinese medical syndrome, high-sensitivity C-reactive protein （hs-CRP）, platelet aggregation rate and the score evaluated by Seattle Angina Questionnaire were compared with those before treatment in the two groups. Results： The total effective rate of the treatment group was 76% and that of control group was 46%, and the difference between the two groups was significant（P 〈 0.05）. After treatment, the score of traditional Chinese medical syndrome, hs-CRP, and platelet aggregation rate in the treatment group were significantly decreased （P 〈 0.05 compared with those before treatment）, and the scores of some Seattle Angina Questionnaire items were greatly improved as compared with those in the control group （P 〈 0.05 or P 〈 0.01）. Conclusion： Heat-clearing and Blood-activating Recipe shows certain effect on relieving symptoms, reducing serum hs-CRP level and improving inflammatory reaction in the treatment of ACS patients.

关 键 词：急性冠脉综合征 冠心病 中医疗法 清热活血方 热毒血瘀 超敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]