中性粒细胞防御素与肺部疾病的研究进展  

Advancement of human neutrophil peptides and its role in lung diseases

作　　者：霍琼芬[1] 朱黎明 戴爱国 

机构地区：[1]南华大学研究生院,衡阳421001 [2]湖南省老年医院老年呼吸科,长沙410016

出　　处：《国际呼吸杂志》2012年第14期1075-1079,共5页International Journal of Respiration

基　　金：湖南省自然科学基金（09JJ5021）;湖南省科技计划项目基金（2007SK3080）;湖南省卫生厅基金（2007166）

摘　　要：人中性粒细胞肽（humanneutrophilpeptides，HNPs）主要是由活化的中性粒细胞释放的阳离子多肽，因具有多种生物学特性而受到广泛关注。越来越多的研究证明，HNPs与中性粒细胞在中性粒细胞气道炎症中共同参与肺组织的损伤与修复。本文就HNPs的结构特点、生物学特性及功能、与中性粒细胞的相互关系、对肺上皮细胞的影响及其在中性粒细胞相关的炎症性肺疾病中的表达情况进行了综述，为临床研究提供新的方向。Human neutrophil peptides （HNPs） are small cationic polypeptides primarily released from activated neutrophils, which attract extensive attention for its biological characteristics. More and more studies show that HNPs and neutrophils promote the development and progression of airway inflammation due to neutrophil, and are involved in lung epithelial cell injury and repair. This paper reviews the structural features, biological characteristics and the function of HNPs, the relationship between neutrophils and HNPs, the influence of HNPs to lung epithelial cell and the expression of HNPs in patients with neutrophil-related inflammatory lung diseases, and provides a new direction for the clinical research.

关 键 词：中性粒细胞肽 中性粒细胞 肺上皮细胞 疾病 

分 类 号：R563[医药卫生—呼吸系统]