阿折地平降压效果评价及其抑制动脉粥样硬化的作用  

Evaluation on curative effect of azelnidipine on hypertension and its inhibitory effect on atherosclerosis

作　　者：焦海旭[1] 张明秋[1] 赵金艳[2] 陈晓帅[1] 

机构地区：[1]吉林大学中日联谊医院心内科,吉林长春130033 [2]吉林省梨树县第一人民医院急诊科,吉林梨树136500

出　　处：《吉林大学学报（医学版）》2012年第4期736-740,共5页Journal of Jilin University：Medicine Edition

基　　金：吉林省卫生厅科研基金资助课题(20082007)

摘　　要：目的:探讨长效二氢吡啶类(DHPS)降压药物阿折地平对高血压病患者的降压效果及对血浆超敏C反应蛋白(hs-CRP)、超氧化物歧化酶(SOD)、6-酮前列腺素F1α(6-keto-PGF1α)水平的影响,阐明阿折地平的降压效果及其抑制动脉粥样硬化(As)的作用。方法:48例高血压病患者随机分为阿折地平组(24例)和氨氯地平组(24例),2组患者经过2周药物洗脱期后,分别给予8周的阿折地平(8～16mg.d-1)或苯磺酸氨氯地平(安内真,5～10mg.d-1)治疗,治疗前后检测患者血压、血液生化指标及血浆hs-CRP、SOD、6-keto-PGF1α水平并进行比较。结果:2组患者治疗后收缩压(SBP)和舒张压(DBP)均显著下降,阿折地平组血压降低总有效率为87.5%,氨氯地平组为91.7%,2组比较差异无统计学意义(P>0.05)。2组患者治疗前后血液生化指标比较差异无统计学意义(P>0.05)。2组患者治疗前血浆hs-CRP、SOD和6-keto-PGF1α水平比较差异无统计学意义(P>0.05);与治疗前比较,2组患者治疗后hs-CRP显著下降(P<0.05),SOD显著升高(P<0.05);阿折地平组患者6-keto-PGF1α在治疗后有升高趋势(P<0.05),而氨氯地平组患者则无明显变化(P>0.05)。结论:阿折地平具有显著的降压疗效,同时对As有抑制作用。Objective To observe the influence of azelnidipine in clinical efficacy and serum levels of high sensitive C-reactive protein（hs-CRP）,superoxide dismutase（SOD） and 6-ketone prostaglandins F1α（6-keto-PGF1α） in patients with hypertension and to clarify the effectiveness of azelnidipine on realeasing blood pressure and suppressing the development of atherosclerosis（AS）.Methods 48 patients with hypertension were randomly divided into azelnidipine group（n=24） and amlodipine besylate group（n=24）.After two-week drug clearance,the patients in two group receieved azelnidipine（8-16 mg·d-1） or amlodipine besylate（5-10 mg·d-1） for 8 weeks.The blood pressure and the serum levels of hs-CRP,SOD and 6-keto-PGF1α before and after treatment were detected and compared.Results The systotlic blood pressure（SBP） and diastolic blood pressure（DBP） of the patients in two groups were significantly decreased,the effective rates in azelnidipine group and amlodipine besylate group were 87.5 and 91.7%,there was no significant difference between two groups（P〉0.05）.There was no significant difference of blood biochemisal indexes of the patients between two groups before and after treatment（P〉0.05）.There were no significant differences of plasma hs-CRP,SOD,and 6-keto-PGF1α of the patients between two groups before and after treatment（P〉0.05）.Compared with before treatment,the hs-CRP levels of the patients in two groups were significantly decreased（P〈0.05）,the SOD levels were increased（P〈0.05）;the 6-keto-PGF1α level of the patients in azelnidipine group after treatment was increased（P〈0.05）,but there was no change in amlodipine besylate group（P〉0.05）.Conclusion Azelnidipine can significantly decrease the blood pressure.It inhibit the formation and development of atherosclerosis.

关 键 词：高血压 阿折地平 苯磺酸氨氯地平 动脉粥样硬化 超敏C反应蛋白 超氧化物歧化酶 6-酮前列腺素F1Α 

分 类 号：R969[医药卫生—药理学]