支气管扩张患者痰培养检出菌及药敏结果分析  

Clinical analysis of sputum bacterial culture and results of antibiotic resistance in patients with bronchiectasis

作　　者：王新霞[1] 刘双[1] 杨京华[1] 朱光发[1] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所呼吸科,北京100029

出　　处：《心肺血管病杂志》2012年第4期448-451,共4页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:分析支气管扩张患者痰培养检出菌的分布及对抗菌药物的敏感性,为临床提供药物治疗依据。方法:对2007年7月至2011年7月,对北京安贞医院住院的212例支气管扩张患者,痰致病菌培养及药物敏感结果进行回顾性分析。结果:本组212例患者病原菌检出阳性95例(44.81%),共分离出细菌96株,铜绿假单胞菌29株(30.2%),肺炎克雷伯杆菌7株(7.29%),嗜麦芽假单胞菌4株(4.17%),大肠埃希氏菌3株(3.13%),产气肠杆菌2株(2.08%),阴沟肠杆菌2株(2.08%),弗氏柠檬酸杆菌2株(2.08%),荧光假单胞菌2株(2.08%),洋葱伯克霍尔德式菌1株(1.04%),醋酸钙-鲍曼氏不动杆菌10株(10.42%),醋酸钙不动杆菌2株(2.08%),鲍曼氏不动杆菌4株(4.17%),鲁氏不动杆菌1株(1.04%),金黄色葡萄球菌12株(12.50%),表皮葡萄球菌4株(4.17%),溶血葡萄球菌2株(2.08%),模拟葡萄球菌1株(4.17%),缓动链球菌1株(1.04%),铅黄肠球菌1株(1.04%),粪肠球菌2株(2.08%),白色假丝酵母4株(4.17%)。结论:支气管扩张患者病原菌占前3位的分别是铜绿假单胞菌、金黄色葡萄球菌、醋酸钙-鲍曼氏不动杆菌。真菌感染应值得关注。提示支气管扩张患者应合理选用抗生素药物。Objective：To investigate the distribution and drug sensitivity of the bacteria obtained from sputum of patients with bronehieetasis and to provide scientific evidence for clinical therapy. Methods：Sputum bacterial culture and drug sensitive test of 212 bronchiectasis patients admitted into Beijing Anzhen Hospital from July 2007 to July 2011 were analyzed retrospectively. Results ： There were 95 positive cases （ 44. 81% ） from sputum culture among 212 patients. Ninty-six bacteria strains were isolated in total, which included 29 ca- ses of Pseudomonas aeruginosa （30.2%） , 7 cases of Klebsiella pneumoniae （7. 29% ） ,4 cases of Pseudo- monas maltophilia （ 4. 17% ）, 3 cases of Escherichia coli （ 3.13% ）, 2 cases of Enterobaeter aerogenes （2.08%）, 2 cases of Enterobacter cloacae （2. 08% ） ,2 cases of Citrobacter freundii （2. 08% ） ,2 cases of Pseudomonas fluoreseens （2. 08% ）, 1 case of Burkholderia cepacia （1.04%）, 10 cases of Calcium Acetate- Bowman Acinetobaeter （ 10.42% ）, 2 eases of Acinetobacter caleoacetieus （2. 08% ）, 4 cases of Aeinetobacter baumannii （ 4. 17% ） , 1 case of Aeinetobacter lwoffii （ 1.04% ） , 12 eases of Staphylocoeeus aureus （12. 50% ）, 4 eases of Staphylococcus epidermidis （4. 17% ）, 2 cases of Staphyloeoecus haemolytieus （2. 08% ）, 1 ease of Simulation anreus （ 1. 04% ）, 1 ease of Slow moving Streptococcus （ 1. 04% ）. 1 ease of En- teroeoecus easselifavus （1. 04% ）, 2 cases of Enteroeoccus faeealis （2. 08% ） and 4 cases of Candida albi- cans （4. 17% ）. Conclusion：The top three bacteria are Pseudomonas aeruginosa and Staphylococcus aureus and Calcium Acetate-Bowman Acinetobacter in patients with bronchiectasis. Clinicians should pay more atten- tion to fungal infection and rationally use antibiotics for the patients.

关 键 词：支气管扩张 细菌培养 药物敏感试验 

分 类 号：R56[医药卫生—呼吸系统]