聚乙二醇干扰素治疗儿童与成人慢性肝炎的不良反应对照分析  

Pegylated Interferon Therapy for Chronic Hepatitis in Children and Adult Adverse Reaction Control Analysis

作　　者：刘安述[1] 刘荣芬[1] 

机构地区：[1]山东省昌邑市人民医院,山东昌邑261300

出　　处：《中国医药指南》2012年第19期62-63,共2页Guide of China Medicine

摘　　要：目的 对比分析聚乙二醇干扰素治疗儿童与成人慢性肝炎的临床不良反应.方法 选取在2008 年4 月至2010 年9 月间在我院进行治疗的100 例慢性肝炎患者的相关资料,将其按照年龄分为治疗组与对照组,治疗组31 例均为16 岁以下患者,对照组69 例均为16 岁以上患者.所有患者均采用聚乙二醇干扰素治疗1 个月,观察其用药期间身体各项指标,总结不良反应情况.结果 治疗组患者不良反应种类低于对照组,所占比例则高于对照组.两组患者头痛、关节肌肉酸痛以及发热为主要不良反应.儿童在用药后1 周时体温一般在37.5～38.0℃,用药第二周时体温一般在38.0～39.2℃;成人体温一般在38.0～38.5℃;两组患者基本上都于首次用药后的12 小时内出现发热情况,而第二次用药时成人多在6 个小时左右出现发热情况,儿童患者在3～8 个小时出现发热情况,而第三次用药后两组患者则均于3～5 小时出现发热情况;成人患者多数在首次用药后即需要采用药物降温,但从第二次用药后所需采用药物降温的例数降低.结论 析聚乙二醇干扰素治疗儿童与成人慢性肝炎效果显著,但临床不良反应较多,儿童不良反应率较高,但发病类型则少于成年人.临床用药应该循序渐进,根据患者情况增减药量.Objective Comparative analysis of pegylated interferon in the treatment of children with adult chronic hepatitis clinical adverse reaction. Methods In 2008 April to 2010 September in our hospital for treatment of 100 cases of patients with chronic hepatitis related information, be in accordance with the age is divided into the treatment group and the control group, 31 cases in the treatment group were below the age of 16patients, 69 cases of the control group were 16 patients over the age. All patients were treated with pegylated interferon in the treatment of one month, its use during the observation of the physical indicators, summarize the adverse reaction. Results The treatment group patients with poor response types were lower than the control group; the proportion is higher than that of the control group. Two groups of patients with headache, joint muscle soreness and fever as major adverse reactions. Children in the medication after one week when the body temperature is generally 37.5 to 38 degrees Celsius, medication second weeks when the body temperature is generally 38 to 39.2 degrees Celsius; adult body temperature is generally 38 to 38.5 degrees Celsius; two groups of patients are basically for the first time after administration of the 12 hours of the onset of fever cases, whereas the second medication adult in 6 hours of fever cases, pediatric patients at 3 to 8 hours of fever, and third times after administration of two groups of patients were from3 to 5 hours of fever; adult patients most at the time after the initial dose is needs to use the drug cooling, but from second time after administration of the drug cooling required to reduce the number of cases. Conclusion Analysis of pegylated interferon in the treatment of children with adult chronic hepatitis effect is remarkable, but the clinical adverse reaction is more, children＇s adverse reaction rate is higher, but the type of onset is less than adults. Clinical medication should be gradual, increase or decrease the dosage according to the sit

关 键 词：聚乙二醇干扰素 儿童慢性肝炎 成人慢性肝炎 不良反应 对比分析 

分 类 号：R512.6[医药卫生—内科学]