大黄对兔血小板中花生四烯酸代谢的影响  

Effects of Rhubarb on Arachidonic Acid Metabolism in Rabbit Platelet

作　　者：郭昌燕[1] 赵淑颖[1] 王宝恩[1] 林成仁[2] 王敏[2] 吴余升[2] 孙晓明[3] 

机构地区：[1]北京友谊医院 [2]中医研究院西苑医院 [3]中国药科大学

出　　处：《北京医学》1989年第4期221-223,共3页Beijing Medical Journal

摘　　要：本文采用放射薄层层析、放射自显影等技术,了解大黄对兔血小板中花生四烯酸代谢的影晌。结果表明,大黄影响血栓素B_2和17一三烯酸的生物合成,且抑制作用呈很好的量效关系。推测抑制合成在环氧化酶通路;与此同时,脂氧化酶代谢终产物羟基花生四烯酸合成增加,显示大黄使脂氧化酶通路活跃。The effects of Rhubarb on arachidonic acid metabolism in rabbit platelets were studied with studied with radiochromatography and radioautograpy The results indicate that the Rhubarb blocked the biosythesis of platelet thromboxane B 2 and 17-hydroxytrialkene in a dose-dependent manner. Meantime, the Rhubarb enhanced hydroxyeicosatetraenoic acid level. The mechanism of action of the Rhubarb is shown to be inhibition of cyclo-oxygenase activities.

关 键 词：大黄 血小板 花生四烯酸 药理 

分 类 号：R285.6[医药卫生—中药学]