Effect of sumatriptan on gastric emptying:A crossover study using the BreathID system  

作　　者：Yasunari Sakamoto Yusuke Sekino Eiji Yamada Takuma Higurashi Hidenori Ohkubo Eiji Sakai Hiroki Endo Hiroshi Iida Takashi Nonaka Koji Fujita Masato Yoneda Tomoko Koide Hirokazu Takahashi Ayumu Goto Yasunobu Abe Eiji Gotoh Shin Maeda Atsushi Nakajima Masahiko Inamori 

机构地区：[1]Gastroenterology Division,Yokohama City University Hospital,3-9 Fukuura,Kanazawa-ku,Yokohama,Kanagawa 236-0004,Japan [2]Department of Medical Education,Yokohama City University School of Medicine,3-9 Fukuura,Kanazawa-ku,Yokohama,Kanagawa 236-0004,Japan [3]Office of Postgraduate Medical Education,Yokohama City University Hospital,3-9 Fukuura,Kanazawaku,Yokohama,Kanagawa 236-0004,Japan

出　　处：《World Journal of Gastroenterology》2012年第26期3415-3419,共5页世界胃肠病学杂志（英文版）

摘　　要：AIM:To determine the effect of oral sumatriptan on gastric emptying using a continuous 13 C breath test(BreathID system).METHODS:Ten healthy male volunteers participated in this randomized,2-way crossover study.The subjects fasted overnight and were randomly assigned to receive a test meal(200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg(sumatriptan condition),or the test meal alone(control condition).Gastric emptying was monitored for 4 h after administration of the test meal by the 13 C-acetic acid breath test performed continually using the BreathID system.Then,using Oridion Research Software(β version),the time taken for emptying of 50% of the labeled meal(T 1/2) similar to the scintigraphy lag time for 10% emptying of the labeled meal(T lag),the gastric emptying coefficient(GEC),and the regression-estimated constants(β and κ) were calculated.The statistical significance of any differences in the parameters were analyzed using Wilcoxon's signed-rank test.RESULTS:In the sumatriptan condition,significant differences compared with the control condition were found in T 1/2 [median 131.84 min(range,103.13-168.70) vs 120.27 min(89.61-138.25);P = 0.0016],T lag [median 80.085 min(59.23-125.89) vs 61.11 min(39.86-87.05);P = 0.0125],and β [median 2.3374(1.6407-3.8209) vs 2.0847(1.4755-2.9269);P = 0.0284].There were no significant differences in the GEC or κ between the 2 conditions.CONCLUSION:This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.AIM：To determine the effect of oral sumatriptan on gastric emptying using a continuous 13 C breath test（BreathID system）.METHODS：Ten healthy male volunteers participated in this randomized,2-way crossover study.The subjects fasted overnight and were randomly assigned to receive a test meal（200 kcal/200 mL） 30 min after pre-medication with sumatriptan 50 mg（sumatriptan condition）,or the test meal alone（control condition）.Gastric emptying was monitored for 4 h after administration of the test meal by the 13 C-acetic acid breath test performed continually using the BreathID system.Then,using Oridion Research Software（β version）,the time taken for emptying of 50% of the labeled meal（T 1/2） similar to the scintigraphy lag time for 10% emptying of the labeled meal（T lag）,the gastric emptying coefficient（GEC）,and the regression-estimated constants（β and κ） were calculated.The statistical significance of any differences in the parameters were analyzed using Wilcoxon＇s signed-rank test.RESULTS：In the sumatriptan condition,significant differences compared with the control condition were found in T 1/2 [median 131.84 min（range,103.13-168.70） vs 120.27 min（89.61-138.25）;P = 0.0016],T lag [median 80.085 min（59.23-125.89） vs 61.11 min（39.86-87.05）;P = 0.0125],and β [median 2.3374（1.6407-3.8209） vs 2.0847（1.4755-2.9269）;P = 0.0284].There were no significant differences in the GEC or κ between the 2 conditions.CONCLUSION：This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.

关 键 词：SUMATRIPTAN Gastric emptying Breath test Liquid meal BreathID system 

分 类 号：R965[医药卫生—药理学]