正常高值血压合并空腹血糖受损患者血清转化生长因子β1水平的探讨  

To explore the serum level of transforming growth factor-β （ TGF-β1） in patients with prehyper- tension and impaired fasting blood glucose

作　　者：张娟娟[1] 张福业 岳峰[4] 李桂英[1] 张琨[3] 

机构地区：[1]泰安市第四人民医院心内科,山东省泰安271000 [2]泰安市第四人民医院院办,山东省泰安271000 [3]泰安市第四人民医院检验科,山东省泰安271000 [4]泰安市中心医院内分泌科

出　　处：《中国医师杂志》2012年第7期895-897,共3页Journal of Chinese Physician

基　　金：山东省泰安市科委资助项目（20113078）

摘　　要：目的探讨正常高值血压合并空腹血糖受损患者血清转化生长因子131（TGF-β1）水平的变化。方法选择年龄及性别相匹配的健康体检者180例。根据血压及空腹血糖水平分为3组：A组（对照组）（血压〈120／80mmHg，空腹血糖〈6．1mmol／L组）60例，B组（正常高值血压＋空腹血糖〈6．1mmol／L组）60例，C组（正常高值血压＋6．1mmol／L≤空腹血糖≤7．0mmol／L组）60例。ELISA法测定TGF-β1水平，同时检测空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL—C）、尿酸、体重质量指数（BMI）。结果B组和C组TGF-β1水平明显高于对照组（t=2．071、2．147，P〈0．05），C组TGF-β1水平高于B组但其差异无统计学意义（P〉0．05）。Pearson相关分析显示TGF-β1与收缩压间呈正相关（r=0．279，P=0．047）。结论正常高值血压患者血清TGF-β1水平升高，TGF-β1可能介导了正常高值血压患者的靶器官损害。Objective To explore the level of serum transforming growth factor-β1 （TGF-β1） in patients with prehypertension and impaired fasting blood glucose. Methods A total of 180 healthy subjects with matched age and sex was divided into 3 grouPs： group A （blood pressure 〈 120/80 mmHg and fasting blood glucose 〈6. 1 mmol/L）, group B （prehypertension and fasting blood glucose 〈6. 1 mmol/L）, group C （prehypertension and 6. 1 mmol/L≤ fasting blood glucose ≤7.0 mmol/L）. There were 60 subjects in every group. Serum TGF-I31 was measured by Enzyme-Linked Immunosobent Assay （ELISA）, fasting blood glu- cose, triglyceride, total cholesterol, low-density lipoprotein cholesterol （ LDL-C）, high - density lipoprotein cholesterol （HDL-C）, Uric Acid （UA）, body mass index （BMI） were determined. Results The level of serum TGF-β1 in group B and C was higher in that in group A（ t =2. 071, and 2. 147, P 〈0.05）. The level of serum TGF-β1 was higher in group C than group B, but no significant difference was observed （ P 〉 0. 05）. The pearson correlation analysis showed there was a significant correlation between TGF-I31 and sys- tolic blood pressure （ r =0. 279, P =0. 047）. Conclusions The level of serum TGF-β1 was higher in patients with prehypertention which may mediate the target organ damage caused by the prehypertention.

关 键 词：高血压前期/并发症/代谢 葡糖耐受不良 血糖/代谢 转化生长因子β1/血液 

分 类 号：R587.1[医药卫生—内分泌]