坦索罗辛促进肾结石体外冲击波碎石后的排石疗效观察  

Observation of tamsulosin promoting stone expulsion after ESWL in renal calculus patients

作　　者：汪隆旺[1] 马彦[1] 刘梅[2] 杨栋[3] 杨雄[1] 文红壮[4] 韩晓敏[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院泌尿外科,武汉430022 [2]华中科技大学同济医学院附属协和医院麻醉科 [3]河南省肿瘤医院泌尿外科 [4]邯郸市中心医院泌尿外一科

出　　处：《临床泌尿外科杂志》2012年第8期575-577,共3页Journal of Clinical Urology

摘　　要：目的:观察α受体阻滞剂坦索罗辛配合ESWL术后的辅助排石作用。方法:将2009年8月～2011年9月收治193例肾结石患者随机分为两组,治疗组除常规治疗外,每日清晨口服坦索罗辛0.4mg。观察排石率、结石平均排出时间、肾绞痛发生率及止痛药使用率等,所有患者每周复查B超及KUB。结果:治疗组的排石率为95.8%,而对照组为78.4%,结石平均排出时间分别为4.2及9.6天,两组肾绞痛发生率及止痛药使用率等均差异有统计学意义(P<0.05)。治疗组中输尿管结石残留、石街形成、需再次ESWL或者输尿管镜检查术等均显著减少。结论:α受体阻滞剂坦索罗辛配合ESWL术可明显提高结石排出率,减少排石时间,缓解治疗期间肾绞痛的发生,效果好于单纯ESWL。Objective： To observe the efficacy of adjunctive treatment of tamsulosin after α single electronic shock wave lithotripsy（ESWL）in patients with renal calculus. Methods：A total of 193 patients with solitary renal calculus after single ESWL were randomly divided into two groups who were admitted in our hospital between Au- gust 2009 and September 2011. Patients in control group received a standard therapy for three days, and those in treatment group were given additional tamsulosin 0.4 mg/d. The primary endpoints were the stone expulsion rate, stone expulsion time, rate of renal colic episodes and utilization rate of analgesic drugs. The examinations of abdom- inal ultrasound scans and KUB X-rays were performed weekly in all patients. Results：The total stone expulsion rate was higher in treatment group than that in control group（95.8% vs78.4%）（P〈0.05）. The stone expulsion time （4.2 d vs 9.6 d）,rate of renal colic episodes and Utilization rate of analgesic drugs were significantly reduced in treatment group patients（P〈0.05）. Residual ureteral stones,formation of steinstrasse,numbers of secondary ES- WL or ureteroscopy were also significantly reduced in the treatment group. Conclusions： Adjunction of tamsulosin after a single ESWL for renal calculus significantly increases the stone expulsion rate and decreases the stone ex- pulsion time and rate of renal colic episodes. Tamsulosin as an adjuvant promoting stone expulsion after ESWL in patients with renal calculus showed an excellent stone expulsive effectiveness.

关 键 词：肾结石 坦索罗辛 体外冲击波碎石 

分 类 号：R692.4[医药卫生—泌尿科学]