卡维地洛传递体的制备及其质量评价  

Preparation and Quality Evaluation of Carvedilol Transfersomes

作　　者：方夏琴[1,2] 何永志[1] 郑稳生[2] 张宇佳 王璐璐[2] 

机构地区：[1]天津中医药大学,天津300193 [2]中国医学科学院/北京协和医学院药物研究所,北京100050

出　　处：《中国药房》2012年第29期2732-2734,共3页China Pharmacy

摘　　要：目的:制备卡维地洛(CA)传递体,并进行质量评价。方法:采用薄膜分散法联合高压乳匀法制备CA传递体;高效液相色谱法测定其中CA的含量;SephadexG-50凝胶柱层析法测定其中CA的包封率;对CA传递体的外观、形态、粒径及电位进行考察。结果:制备的CA传递体为乳白色、近均一透明的胶体溶液;CA平均含量为27.09μg·mL-1,平均包封率为80.84%,RSD均<2.0%;体系粒径在100nm左右,多分散性系数为0.05左右,电位均>41mV,具有较好的质量和稳定性。结论:CA传递体制备工艺可行、方法简单、质量可控。OBJECTIVE： To prepare Carvedilol transfersomes, and to evaluate the quality of it. METHODS： Carvedilol trans-fersomes were prepared by film dispersion and high-pressure homogenization. The content of carvedilol was determined by HPLC, and the entrapment efficiency of carvedilol transfersomes was determined by using Sephadex G-50 chromatography; the appear-ance, shape, particle size and Zeta potential of transfersomes were evaluated. RESULTS： Carvedilol transfersomes were colloid so- lution in ivory white color, nearly uniform and transparent. The average content of carvedilol was 27.09 μg·mL^-1, and average en- trapment efficiency was 80.84% （all the RSD〈2.0% ） ; the particle size was about 100 nm, polydispersity index was about 0.05, the Zeta potential was more than 41 mV. The preparation had good quality and stability. CONCLUSION： The preparation technolo-gy of Carvedilol transfersomes is feasible, simple and controllable in quality.

关 键 词：卡维地洛 传递体 高效液相色谱法 粒径 电位 

分 类 号：R972[医药卫生—药品] R944.9[医药卫生—药学]