高脂血症红细胞表面超微结构改变的临床观察  

Clinical Observation of the Changes of Red Blood Cell Surface Ultrastructure in Patients with Hyperlipidemia

作　　者：郑家胜[1] 诸葛毅[1] 俎德玲[1] 

机构地区：[1]衢州职业技术学院医学院,浙江省衢州市人民医院心血管内科324000

出　　处：《心电与循环》2012年第4期220-222,共3页Journal of Electrocardiology and Circulation

摘　　要：目的 分析高脂血症患者红细胞表面超微结构的改变,血脂相关参数的改变,加深对高脂血症引起动脉硬化及心脑血管病机制的认识.方法 30例高脂血症患者为观察组,30 例健康体检者为对照组,通过扫描电镜观察红细胞表面超微结构,比较两者的差异,并对血脂相关参数进行分析.结果 观察组和对照组的血总胆固醇分别为：（6.85±1.37）mmol / L、（4.19±0.64）mmol / L（P＜0.01）;低密度脂蛋白分别为：（4.26±1.46）mmol / L、（1.54±0.38）mmol / L（P＜0.01）;扫描电镜下,呈圆拱形锅盖状异常形态红细胞明显增多,部分红细胞互相粘连呈串状或簇状,对照组红细胞形态多呈双凹圆盘状.结论 高脂血症患者胆固醇、低密度脂蛋白水平升高,红细胞表面超微结构显著改变,可能是导致动脉硬化及心脑血管急性事件的红细胞病理基础.Objective To observe the change of hyperlipidemia patient＇s red blood cell （RBC） surface ultrastructure and analyzed some related blood lipid parameters, to understand that hyperlipidemia is predisposition to arteriosclerosis and some correlative cerebrovascular disease mechanism. Methods A total of 30 cases of patients with hyperlipidemia as objective group and 30 cases of healthy people as control group were observed with the RBC surface ultrastructure in the two groups using scanning electron microscope （SEM） and their difference were found, the related blood lipid parameters in the two groups were analyzed. Results The evidence that the objective group and control group data shows respectively as： total cholesterol,（ 6.85 ± 1.37）mmol/L, （4.19 ± 0.64）mmol/L （P〈0.01）; low-density iipoprotein cholesterol, （4.26 ± 1.46） mmol/L, （1.54 ± 0.38） mmol/L（ P〈0.01 ）. The SEM observation showed that the objective group samples＇ RBC with domed shape had increased a lot, and some clusters were formed for the adhesion of RBC, while the control group samples＇ RBC displayed as bis concave disks. Conclusion There is higher level of serum total cholesterol and low-density lipoprotein cholesterol in 30 cases of patients with hyperlipidemia than healthy people. The fact shows that hy- perlipidemia patient＇s RBC surface ultrastructure changes is significant and RBC pathological basis for arteriosclerosis and occurrence of acute cardiovascular events is present.

关 键 词：高脂血症 红细胞 超微结构 动脉硬化 

分 类 号：R589.2[医药卫生—内分泌]