基于物质基础组分的中药多元释药系统研究思路与应用  

Thought and application of traditional Chinese medicine multiple drug delivery system based on material basis component

作　　者：孙娥[1] 贾晓斌[1,2] 黄洋[1,3] 陈斌[1] 胡琴[1,3] 萧伟[2] 

机构地区：[1]江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]中药制药过程新技术国家重点实验室(筹),江苏连云港222001 [3]江苏大学药学院,江苏镇江212013

出　　处：《中国中药杂志》2012年第14期2181-2185,共5页China Journal of Chinese Materia Medica

基　　金：江苏省中医药领军人才项目(2006);中药制药过程新技术国家重点实验室开放基金项目(SKL2010Z0303);江苏省中医药科技项目(LZ09061,LZ09067)

摘　　要：该文针对中药制剂的研究现状,以"整体观念"和"辨证论治"为指导,依据中药多组分、多靶点、多效应的特点,提出"基于物质基础组分的中药多元释药系统"研究思路,建立"以物质基础组分为前提,以提高生物利用度为目的,构建中药多元释药系统"的中药制剂研究新模式,并以通脉微丸多元释药系统为例进行阐述,为中药现代给药系统的深入发展提供新的策略和方法。To aim directly at the research status of Chinese drugs pharmaceutics, this study provides a new research idea ＂traditional Chinese medicine multiple drug delivery system based on material basis component＂. This thought according to whole concept, syndrome, and Chinese medicine characteristics of multi-component, multi-target, muhi-effect. The premise of designing traditional Chinese medicine multiple drug delivery system is material basis component, and the purpose is to improve bioavailability. The example of multi-drug delivery system of tongmai micro-pellets is expounded for application. This new research model of Chinese drugs pharmaceutics provides new strategies and methods for the development of modern Chinese drug delivery systems.

关 键 词：中药多元释药系统 物质基础组分 生物利用度 通脉微丸 

分 类 号：R285[医药卫生—中药学]