肿瘤坏死因子-α和转化生长因子-β基因多态性与尘肺易感性的Meta分析  

Meta-analysis of association of tumor necrosis factor alpha and transforming growth factor beta gene polymorphisms with Pneumoconiosis

作　　者：刘乾[1] 苏文珍[2] 单永乐[1] 张志虎[1] 许光[1] 张玮[1] 张海东[1] 王瑞[1] 

机构地区：[1]山东省医学科学院职业卫生与职业病防治研究院检测与评价科,济南250062 [2]山东省交通医院骨外科,济南250062

出　　处：《中华劳动卫生职业病杂志》2012年第8期587-592,共6页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金项目（30872094）;山东省科技攻关项目（2008GG30002036）

摘　　要：目的评价肿瘤坏死因子-α（TNF-α）238、转化生长因子-β（TGF-β）（509和869）位点基因多态性与尘肺易感性。方法检索Elsevier、PubMed、WileyOnline Library、EMCC、Web0fScience外文数据库和中国期刊全文数据库、维普数据库、万方数据库、中国生物医学文献数据库中文数据库及Cochrane图书馆文献（1988年1月至2011年8月），收集上述基因位点与尘肺易感性的病例对照研究或队列研究。共检索到28篇相关文献，20篇纳入研究。应用RevMan4．2软件对各研究结果进行异质性检验和效应值合并。结果20篇纳入研究中有TNF-α238位点文献10篇（涉及2232例尘肺患者和1985例对照人群），TGF-β509位点文献4篇（涉及693例尘肺患者和663例对照人群），TGF-β869位点文献6篇（涉及1450例尘肺患者和1101例对照人群）。Meta分析结果表明，TNF-α238位点基因多态性与尘肺易感性相关：携带GA＋AA基因型的个体患尘肺的风险性高于GG基因型个体（OR=I．53，95％CI：1．25-1．88）；携带A等位基因的个体患尘肺的风险性高于G等位基因个体（OR=1．64，95％CI：1．17-2．30）；分层分析显示，矽肺人群、亚洲人群和接尘工人中携带GA＋AA基因型和A等位基因患尘肺的风险性增高（OR=2．14，95％Ch1．20-3．82；OR=2．16，95％CI：1．20-3．88；OR=I．78，95％CI：1．0l-3．11；OR=1．83，95％Ch1．04-3．22；OR=1．80，95％Ch1．21-2．66；OR=1．50，95％CI：1．23-1．83）。TGF．B（509和869）位点基因多态性与尘肺易感性的相关性无统计学意义：携带CT＋Tr基因型个体患尘肺的风险性不高于CC基因型（OR=I．56，95％CI：0．81-3．01；OR=0．96，95％CI：0．79-1．18），携带T等位基因的个体患尘肺的风险性不高于C等位基因（OR=I．35，95％CI：0．86-2．13；OR=1．02，95％CI：0．91-1．15）。结论TNF-α238位点基因多态性与尘肺易感性有关，TGF-β（509和869�Objective To evaluate the relationship between tumor necrosis factor-alpha-238, transforming growth factor beta （509 and 869） gene polymorphisms and pneumoconiosis susceptibility. Methods We searched published full-text from foreign language databases including Elsevier, PubMed, Wiley Online Library, EMCC, Web of Science, chinese databases containing CNKI, VIP, Wanfang, CBM and Coehrane library to collect case-control or cohort study on gene gene polymorphisms said above with pneumoconiosis susceptibility from the year January1988 to August 2011.28 relevant articles were selected and 20 of them met the criteria. The correlated index was extracted for aggregate analysis in RevMan 4.2. Results Among the 20 studies, 10 articles on TNF-α238 polymorphism （including 2232 pneumoconiosis cases and 1985 control subjects）, 4 articles on TGF-β509 polymorphism （including 693 pneumoconiosis cases and 663 control subjects）, and 6 articles on TGF-β869 polymorphism （including 1450 pneumoconiosis cases and 1101 control subjects） were included in the current study. Meta-analysis results showed that there was a significant association between TNF-α238 polymorphism and pneumoconiosis： the population with GA and AA genotypes of TNF-α238 had higher risks to pneumoconiosis （OR=1.53, 95%CI： 1.25-1.88） comparing to GG genotype, and the population with A allele had higher risks to pneumoconiosis comparing to allele G （OR=1.64, 95%CI： 1.17-2.30）. The stratified analysis showed that the people with GA and AA genotypes and A allele who weresilicosis, Asian or exposed to dust had higher risks to pneumoconiosis （OR=2.14, 95%CI： 1.20-3.82; 0R=2.16, 95%CI： 1.20-3.88; OR=1.78, 95%CI： 1.01-3.11; OR=1.83, 95%CI： 1.04-3.22; OR=l.80, 95%C1： 1.21-2.66; OR=l.50, 95%CI： 1.23-1.83）. No significant association was found between TGF-[3 （509 and 869） gene poly- morphisms with pneumoconiosis： In contrast to the CC genotype, the population who had CT and T＇F genotypes had no higher risks to pneumoconi

关 键 词：肿瘤坏死因子-Α 转化生长因子-Β 多态性 尘肺 META分析 

分 类 号：R135.2[医药卫生—劳动卫生]