表观扩散系数值在鉴别不同组织学类型肺癌中的价值  

Application value of apparent diffusion coefficient in diagnosis of different histological subtypes of lung cancers

作　　者：陈利华[1] 陈永峰[2] 张久权[1] 王文伟[2] 夏云宝 王健[1] 

机构地区：[1]第三军医大学西南医院放射科,重庆400038 [2]第三军医大学西南医院呼吸科,重庆400038 [3]太湖医院放射科,江苏无锡214044

出　　处：《中国医学影像技术》2012年第8期1541-1545,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨DWI表观扩散系数(ADC)值鉴别肺癌组织学类型的价值。方法对58例高度怀疑肺癌患者(男39例,女19例)行胸部DWI检查,b值选择为50和1000s/mm2,计算ADC值。采用单因素方差分析方法检测不同组织学类型肺癌ADC值的差异,并应用ROC曲线评价ADC值鉴别肺癌组织学类型的能力。结果小细胞肺癌的平均ADC值为(1.02±0.24)×10-3 mm2/s;非小细胞肺癌的平均ADC值为(1.03±0.24)×10-3 mm2/s,其中腺癌、鳞癌的平均ADC值分别为(1.10±0.14)×10-3 mm2/s、(0.89±0.09)×10-3 mm2/s。腺癌的平均ADC值显著高于鳞癌(P<0.001)。在非小细胞肺癌中,腺癌的ROC曲线下面积为0.91±0.04。结论腺癌的平均ADC值显著高于鳞癌;ADC值有助于鉴别肺腺癌和鳞癌。Objective To investigate the possibility of using the apparent diffusion coefficient （ADC） value to differenti- ate histological subtypes of lung cancers. Methods Fifty-eight patients with. suspected lung cancer （59 men, 19 women） underwent magnetic resonance diffusion-weighted imaging （DWI）of the chest with b factor of 50 and 1000 s/mm2. ADC values were calculated and correlated with histological subtypes of lung cancers. ROC analysis of ADC value was used to predict histological subtypes. Results The mean ADC value of small and non-small cell lung cancer was （1.02±0.24） × 10^-3 mm^2/s and （1.03±24）× 10^-3 mm^2/s, respectively, while of squamous cell carcinoma and adenocarcinoma was （0.89±0.09）× 10^-3 mm^2/s and （1.10±0. 14） ×10^-3 mm^2/s, respectively. ADC value of adenocarcinoma was significant- ly higher than that of squamous cell carcinoma （P〈0. 001）. The area under ROC curve was 0.91±0.04 for adenocarcino- ma of non-small cell lung cancer. Conclusion The mean ADC value of lung adenocarcinoma is significantly higher than that of squamous cell carcinoma. ADC value may help to differentiate the histological subtypes of lung cancers.

关 键 词：肺肿瘤 扩散磁共振成像 表观扩散系数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R734.2[医药卫生—诊断学]