帕瑞昔布钠在颈椎间盘突出微创手术患者超前镇痛的效果  

A randomized double-blind placebo-controlled study of preemptive parecoxib sodium effect in pain during minimasive surgery on herniation of cervical disc

作　　者：周卫民[1] 李云[1] 李建军[1] 

机构地区：[1]武汉市汉口医院疼痛科,湖北武汉430012

出　　处：《颈腰痛杂志》2012年第4期266-268,共3页The Journal of Cervicodynia and Lumbodynia

摘　　要：目的探讨帕瑞昔布钠在颈椎间盘突出症微创手术患者超前镇痛的有效性和安全性。方法50例颈椎间盘突出症患者随机分为两组:帕瑞昔布钠组(n=25)和对照组(n=25)。穿刺前20 min给药,采用视觉模拟量表(VAS)记录患者的疼痛评分,记录两组穿刺完成时间,穿刺过程中因疼痛影响穿刺患者的数量,穿刺前、穿刺时和拔针后1 h的VAS评分,拔针后1 h患者对疼痛总体满意度及整个治疗过程中的不良反应。结果两组患者一般资料方面差异无统计学意义(P>0.05);穿刺时疼痛、拔针后疼痛、患者满意度方面,帕瑞昔布钠组明显优于对照组(P<0.05)。结论帕瑞昔布钠对颈椎间盘突出症微创手术患者具有超前镇痛作用。Objective To investigate whether preemptive of parecoxib sodium would influence the reported pain precluded by the interventional technique itself. Methods Fifty patients with herniation of cervical disc pain were randomly allocated into two groups：parecoxib sodium（n=25）and placebo（n=25）. The degree of pain was measured using visual analogs scale（VAS）. Duration of the procedure,the number of patients whose movement interfering the procedure,patients satisfaction after the puncture and the adverse effects were recorded. Patients reported VAS of one hour before puncture ,during puncture and One hour after the removal of the minimasive surgery were recorded. Result The demographic date were similar in the two groups. Procedural pain and after the puncture were significantly decreased with parecoxib administration in comparison with placebo （P〈0.05）. Patients satisfaction was greater with parecoxib sodium in comparison with placebo. Conclusion Parecoxib sodium can be safely used in the minimasive surgery on herniation of cervical disc and it shows a good analgesic effect.

关 键 词：帕瑞昔布钠 颈椎间盘突出症 微创手术 超前镇痛 

分 类 号：R681.55[医药卫生—骨科学]