孟鲁司特钠口服治疗毛细支气管炎近期疗效观察  

Short-term Efficiency of Montelukast Sodium for Bronchiolitis

作　　者：赵凯[1] 陈迎春[1] 何丽萍[1] 梁晓燕[1] 

机构地区：[1]江苏省苏州市立医院(南京医科大学附属苏州医院)本部儿科,215002

出　　处：《中华全科医学》2012年第9期1339-1340,1426,共3页Chinese Journal of General Practice

摘　　要：目的探讨口服孟鲁司特钠片剂治疗毛细支气管炎的近期疗效。方法将2010年1月-2011年3月在苏州市立医院儿科住院且符合纳入标准的52例毛细支气管炎患儿随机分为两组,对照组27例给予常规综合治疗,观察组25例在此基础上加用孟鲁司特钠口服,比较两组在喘憋持续时间、喘息持续时间、住院时间、咳嗽持续时间方面的差异;同时在两组患儿进行治疗前后均检测血清IgE、IL-4、IFN-γ水平,加以对照。结果孟鲁司特钠口服观察组在细湿啰音持续时间、住院时间、咳嗽持续时间方面优于常规治疗对照组,差异有统计学意义(P<0.05),喘憋持续时间则无明显差异;两组治疗后血清IgE、IL-4水平均下降,IFN-γ水平上升,差异存在统计学意义(P<0.05),但孟鲁司特钠口服观察组变化的程度更加明显,差异有统计学意义(P<0.05)。结论口服孟鲁司特钠治疗毛细支气管炎有一定意义,尤其在缩短病程和改善机体免疫失衡方面,但可能对缓解病程最初喘憋危重期病情效果有限。Objective To study of the short-term efficiency of Montelukast sodium on the bronchiolitis. Methods Fifty two infants with bronchiolitis in our hospital from January 2010 to March 2011 were randomly divided into two groups;the control group （n = 27 ） was given the conventional therapy, while the observation group （n=25 ） were administered with Montelukast Sodium based on the conventional therapy. The differences in duration of wheeze and coughing and hospitalization time; meanwhile, the level of serum IgE, IL-4 and IFN-γ, in two groups before and after the treatment were detected. Results The effects of observation group was superior to the control group in duration time of fine tales and coughing and hospitalization time, the differences was statically significant（ P 〈 0.05 ）. There was not statically significant in duration of wheeze（ P 〉 0. 05 ）. The level of serum IgE and IL-4 decreased after therapy, the level of IFN-γ increased, the differences was statically significant（ P 〈 0.05 ）, and the observation group was more significant. Conclusion Montelukast sodium was absolutely significant in the therapy of bronchiolitis, especially in shortening the course of disease and improving host defenses ,but it has limited effects to relieve the wheezing in the early stage.

关 键 词：孟鲁司特钠 毛细支气管炎 婴幼儿 近期疗效 

分 类 号：R562.21[医药卫生—呼吸系统] R725.6[医药卫生—内科学]