Development of sequential type iron salt-catalyzed Nazarov/Michael reaction in an ionic liquid solvent system  

作　　者：IBARA Chie FUJIWARA Masamune HAYASE Shuichi KAWATSURA Motoi ITOH Toshiyuki 

机构地区：[1]Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan

出　　处：《Science China Chemistry》2012年第8期1627-1632,共6页中国科学（化学英文版）

基　　金：supported by a Grant-in-Aid for Scientific Research in a Priority Area, "Science of Ionic Liquids", from the Ministry of Education, Culture, Sports, Science and Technology of Japan

摘　　要：Sequential type one pot Nazarov/Michael reaction of pyrrole derivatives has been demonstrated using 5 tool% Fe（C104）3· A120 as catalyst in an ionic liquid as solvent. We succeeded in obtaining 4,5-dihydrocyclopenta[b]pyrrol-6（1H）-one derivative in good yield for five repetitions of the reactions without any addition of the catalyst using an ionic liquid, [bmim][NTf2], as sol- vent system.Sequential type one pot Nazarov/Michael reaction of pyrrole derivatives has been demonstrated using 5 mol% Fe(ClO4)3·Al2O as catalyst in an ionic liquid as solvent. We succeeded in obtaining 4,5-dihydrocyclopenta[b]pyrrol-6(1H)-one derivative in good yield for five repetitions of the reactions without any addition of the catalyst using an ionic liquid, [bmim][NTf2], as solvent system.

关 键 词：Nazarov cyclization Michael reaction green synthesis iron catalyst ionic liquids 

分 类 号：O643.32[理学—物理化学]