鲑鱼降钙素在膝关节骨关节炎中的应用  

Application of salmon calcitonin in treating knee osteoarthritis

作　　者：李永刚[1] 唐海[2] 

机构地区：[1]首都医科大学附属复兴医院骨科,北京100038 [2]首都医科大学附属北京友谊医院骨科,北京100050

出　　处：《国际外科学杂志》2012年第7期457-461,共5页International Journal of Surgery

摘　　要：目的分析鲑鱼降钙素治疗膝关节骨关节炎的临床疗效。方法将膝关节骨关节炎患者48例按随机数字表法随机分为A、B、C、D4组，每组各12例。每组患者给予不同的药物治疗。A组：对乙酰氨基酚＋盐酸氨基葡萄糖；B组：美洛昔康＋盐酸氨基葡萄糖；C组：鲑鱼降钙素＋盐酸氨基葡萄糖；D组：鲑鱼降钙素。对乙酰氨基酚及美洛昔康在疼痛症状消失后即可停用。其他药物疗程为12周。治疗前后记录对比疼痛视觉模拟评分，用12条目健康调查简表评价患者生活质量变化。结果12周后，A、B、C、D4组疼痛视觉模拟评分由治疗前5．6±1．2、5．5±1．2、5．4±1．0、5．1±1．2降至1．9±0．8、1．2±0．7、0．8±0．6、0．9±0．7；12条目健康调查简表评分由治疗前-23．4±3．1、-23．8±3．0、-24．8±3．8、-22．4±2．8降至-15．1±4．7、-14．5±4．7、-9．3±6．2、-10．2±5．3。各组治疗前后比较，差异明显具有统计学意义（P〈0．05）。B、C、D组患者疼痛视觉模拟评分优于A组（P〈0．05）。C、D组患者12条目健康调查简表评分优于A、B两组（P〈0．05）。结论鲑鱼降钙素治疗膝关节骨关节炎有较好的止痛作用。Objective To study the effect of salmon calcitonin in treating knee osteoarthritis. Methods Forty- eight cases of knee osteoarthritis were randomly divided into four groups, twelve cases each group. A group： aeet- aminophen ± glucosamine hydroehloride, B group ： meloxicam ± glueosamine hydrochloride, C group ： salmen calci- tonin ± glucosamine hydroehloride, D group： salmon ealcitonin. Aeetaminophen and meloxieam can stop as pain symptoms disappeared. Other drugs were treated for 12 weeks. A follow up was carried out to compare visual ana- logue score and 12-item short form health survey. Results Twelve weeks later, A, B, C, D four groups＇ visual analogue score decreased from before treatment 5.6 ± 1.2, 5.5 ± 1.2, 5.4 ± 1.0, 5.1 ± 1.2 to 1.9 ± 0.8, 1.2 ± 0.7, 0.8 ± 0.6, 0.9 ± 0.7, 12-item short form health survey score from before treatment - 23.4 ± 3.1, - 23.8 ± 3.0, -24.8 ±3.8, -22.4 ±2.8 to -15.1±4.71 -14.5 ±4.7, -9.3 ±6.2, -10.2±5.3. There was signif- icant difference before and after treatment in every group （ P 〈 0.05 ）. The visual analogue scores of B, C and D group outweigh A group＇ s （ P 〈 0.05 ）. A and B groups＇ scores of 12-item short form health survey were lower toC and D groups＇ （P 〈 0.05 ）. Conclusions Salmon calcitonin can relieve pain in treating knee osteoarthritis.

关 键 词：骨关节炎 降钙素 疼痛 

分 类 号：R684.3[医药卫生—骨科学]