GABA_BR异二聚体和GB1-GB1同二聚体中的GB1亚基的作用(英文)  

The Role of GB1 Subunit in GABA_BR Heterodimer and GB1-GB1 Homodimer

作　　者：Baloucoune Guillaume Antoine 春雷 黄思罗[1] 

机构地区：[1]华中科技大学生命科学与技术学院分子生物物理教育部重点实验室,湖北武汉430074

出　　处：《现代生物医学进展》2012年第21期4144-4148,共5页Progress in Modern Biomedicine

基　　金：Natural Science Foundation of China(No.31100548,No.30973514)~~

摘　　要：GABABR属于C族G蛋白偶联受体,是中枢神经细胞重要的抑制性神经递质受体。在体内GABABR由GB1和GB2两个基因编码,1998年以来研究者证实GABABR是由GB1和GB2形成的异二聚体,但近年来的研究表明,GB1也可以单独形成GB1-GB1同二聚体并在体内行使功能。本文系统介绍了GB1亚基的分类,在GB2存在或不存在时的表达,以及在GABABR异二聚体和GB1-GB1同二聚体激活过程中所扮演的角色和生理功能;同时也展望了这些研究成果对于基础研究和药学研究的意义。GABABR belongs to the Class C G protein-coupled receptor, and it is important inhibitory neurotransmitter receptors in central nervous system. GABABR is encoding by two genes, GB1 and GB2, and researchers have confirmed that GABAB-R is heterodimer formed by GB1 and GB2 since 1998, but recent studies have shown that GB1 could form GB1-GB1 bomodimer in the absence of GB2 and exercise functions in vivo. In present systematically review the different splice variants of GB1, and its expression in the presence or absence of GB2, and its role in the activation process of GABABR heterodimer and GB1-GB1 homodimer as well as its physiologic effect in vivo; and also prospect the significance of the above studies in basic research and pharmacology.

关 键 词：异二聚体 GBl 亚基 G蛋白偶联受体 抑制性神经递质 GABA 生理功能 神经细胞 

分 类 号：Q25[生物学—细胞生物学] Q27